Malt1 MALT1 paracaspase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Malt1provided by RGD
Official Full Name: MALT1 paracaspaseprovided by RGD
Primary source: RGD:1309195
See related: EnsemblRapid:ENSRNOG00000017181 AllianceGenome:RGD:1309195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pcasp1
Summary: Predicted to enable several functions, including identical protein binding activity; protease binding activity; and ubiquitin-protein transferase activity. Predicted to contribute to kinase activator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of immune response. Predicted to act upstream of or within several processes, including B-1 B cell differentiation; positive regulation of NF-kappaB transcription factor activity; and regulation of T cell receptor signaling pathway. Predicted to be located in cytosol and fibrillar center. Predicted to be part of CBM complex and polkadots. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 220.0), Thymus (RPKM 70.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (61212290..61266272)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (58942282..58996318)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (61108712..61162446)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway.
Title: HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway.
Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway.
Title: Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway.
Targeting of MALT1 May Improve Functional Recovery and Attenuate Microglia M1 Polarization-Mediated Neuroinflammation During Spinal Cord Injury.
Title: Targeting of MALT1 May Improve Functional Recovery and Attenuate Microglia M1 Polarization-Mediated Neuroinflammation During Spinal Cord Injury.
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
Title: The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway.
Title: MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway.
inactivation of MALT1 protease activity caused reduced stimulation-induced T cell proliferation, impaired IL-2 and TNF-alpha production, as well as defective Th17 differentiation.
Title: Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to kinase activator activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B-1 B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to fungus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CBM complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of polkadots	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucosa-associated lymphoid tissue lymphoma translocation protein 1

Names: mucosa associated lymphoid tissue lymphoma translocation gene 1; paracaspase-1

NP_001406694.1

EC 3.4.22.-

NP_001406695.1

EC 3.4.22.-

XP_006254950.1

EC 3.4.22.-

XP_038953326.1

EC 3.4.22.-

XP_038953327.1

EC 3.4.22.-

XP_063133396.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419765.1 → NP_001406694.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D4A980

Related

ENSRNOP00000059281.3, ENSRNOT00000068418.6
NM_001419766.1 → NP_001406695.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I6ARW3

Related

ENSRNOP00000108631.1, ENSRNOT00000164884.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

61212290..61266272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097399.2 → XP_038953327.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X4

Conserved Domains (4) summary

cd08783
Location:36 → 132

Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1

pfam00656
Location:351 → 420

Peptidase_C14; Caspase domain

pfam13927
Location:130 → 200

Ig_3; Immunoglobulin domain

cd00096
Location:150 → 154

Ig; Ig strand B [structural motif]
XM_006254888.5 → XP_006254950.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1

See identical proteins and their annotated locations for XP_006254950.1

UniProtKB/TrEMBL

A6IXQ3

Conserved Domains (6) summary

cd00096
Location:150 → 210

Ig; Immunoglobulin domain

smart00410
Location:139 → 207

IG_like; Immunoglobulin like

pfam07679
Location:242 → 317

I-set; Immunoglobulin I-set domain

cd08783
Location:36 → 132

Death_MALT1; Death domain similar to that found in Mucosa-associated lymphoid tissue-lymphoma-translocation gene 1

pfam00656
Location:351 → 568

Peptidase_C14; Caspase domain

pfam13895
Location:241 → 317

Ig_2; Immunoglobulin domain
XM_063277326.1 → XP_063133396.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2

Related

ENSRNOP00000097032.2, ENSRNOT00000094098.2
XM_039097398.2 → XP_038953326.1 mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X3

Conserved Domains (2) summary

pfam00656
Location:2 → 210

Peptidase_C14; Caspase domain

pfam18703
Location:233 → 369

MALT1_Ig; MALT1 Ig-like domain