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Wac WW domain containing adaptor with coiled-coil [ Rattus norvegicus (Norway rat) ]

Gene ID: 307029, updated on 10-Oct-2024

Summary

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Official Symbol
Wacprovided by RGD
Official Full Name
WW domain containing adaptor with coiled-coilprovided by RGD
Primary source
RGD:1562407
See related
EnsemblRapid:ENSRNOG00000018698 AllianceGenome:RGD:1562407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562407
Summary
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including histone ubiquitination; mitotic G1 DNA damage checkpoint signaling; and regulation of cellular catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 401.2), Lung (RPKM 347.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wac in Genome Data Viewer
Location:
17q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (60617702..60677771)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (55922686..55984286)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (60887606..60946630, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482777 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene DEAD-box helicase 5, pseudogene 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Zhang F, et al. Mol Cell, 2011 Feb 18. PMID 21329877, Free PMC Article
  2. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Xu GM, et al. Genomics, 2002 Jan. PMID 11827461
  3. VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion. Totsukawa G, et al. EMBO J, 2011 Aug 2. PMID 21811234, Free PMC Article
  4. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. McKnight NC, et al. EMBO J, 2012 Apr 18. PMID 22354037, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WAC is hence thought to function in p97/p47-mediated Golgi membrane fusion by activating the deubiquitinating function of VCIP135.
    Title: VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain-containing adapter protein with coiled-coil

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270417.1 → NP_001257346.1  WW domain-containing adapter protein with coiled-coil

    See identical proteins and their annotated locations for NP_001257346.1

    Status: PROVISIONAL

    Source sequence(s)
    AB574169
    UniProtKB/TrEMBL
    A6KPM9, F1LW69, G3XEV5
    Related
    ENSRNOP00000082342.2, ENSRNOT00000116963.2
    Conserved Domains (2) summary
    pfam00397
    Location:133 → 160
    WW; WW domain
    cl21494
    Location:423 → 528
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    60617702..60677771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276468.1 → XP_063132538.1  WW domain-containing adapter protein with coiled-coil isoform X7

  2. XM_039095733.2 → XP_038951661.1  WW domain-containing adapter protein with coiled-coil isoform X7

    UniProtKB/TrEMBL
    A6KPM9
    Related
    ENSRNOP00000055641.6, ENSRNOT00000058852.6
    Conserved Domains (3) summary
    PHA03247
    Location:172 → 490
    PHA03247; large tegument protein UL36; Provisional
    COG5104
    Location:86 → 153
    PRP40; Splicing factor [RNA processing and modification]
    pfam00397
    Location:88 → 115
    WW; WW domain

  3. XM_063276466.1 → XP_063132536.1  WW domain-containing adapter protein with coiled-coil isoform X6

  4. XM_063276472.1 → XP_063132542.1  WW domain-containing adapter protein with coiled-coil isoform X11

  5. XM_063276467.1 → XP_063132537.1  WW domain-containing adapter protein with coiled-coil isoform X7

  6. XM_039095730.2 → XP_038951658.1  WW domain-containing adapter protein with coiled-coil isoform X3

    UniProtKB/TrEMBL
    A6KPM9
    Conserved Domains (3) summary
    PHA03247
    Location:217 → 535
    PHA03247; large tegument protein UL36; Provisional
    COG5104
    Location:131 → 198
    PRP40; Splicing factor [RNA processing and modification]
    pfam00397
    Location:133 → 160
    WW; WW domain

  7. XM_039095738.2 → XP_038951666.1  WW domain-containing adapter protein with coiled-coil isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZWU8, A6KPM9
    Conserved Domains (3) summary
    PHA03247
    Location:195 → 425
    PHA03247; large tegument protein UL36; Provisional
    COG5104
    Location:131 → 198
    PRP40; Splicing factor [RNA processing and modification]
    pfam00397
    Location:133 → 160
    WW; WW domain

  8. XM_063276462.1 → XP_063132532.1  WW domain-containing adapter protein with coiled-coil isoform X1

  9. XM_063276463.1 → XP_063132533.1  WW domain-containing adapter protein with coiled-coil isoform X2

  10. XM_063276464.1 → XP_063132534.1  WW domain-containing adapter protein with coiled-coil isoform X4

  11. XM_063276465.1 → XP_063132535.1  WW domain-containing adapter protein with coiled-coil isoform X5

  12. XM_063276471.1 → XP_063132541.1  WW domain-containing adapter protein with coiled-coil isoform X9

  13. XM_063276470.1 → XP_063132540.1  WW domain-containing adapter protein with coiled-coil isoform X8

  14. XM_063276473.1 → XP_063132543.1  WW domain-containing adapter protein with coiled-coil isoform X12

    Related
    ENSRNOP00000110310.1, ENSRNOT00000100553.2

  15. XM_039095734.2 → XP_038951662.1  WW domain-containing adapter protein with coiled-coil isoform X7

    UniProtKB/TrEMBL
    A6KPM9
    Conserved Domains (3) summary
    PHA03247
    Location:172 → 490
    PHA03247; large tegument protein UL36; Provisional
    COG5104
    Location:86 → 153
    PRP40; Splicing factor [RNA processing and modification]
    pfam00397
    Location:88 → 115
    WW; WW domain

  16. XM_063276469.1 → XP_063132539.1  WW domain-containing adapter protein with coiled-coil isoform X7

RNA

  1. XR_010058876.1 RNA Sequence

  2. XR_010058875.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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