U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HDLBP high density lipoprotein binding protein [ Homo sapiens (human) ]

Gene ID: 3069, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
HDLBPprovided by HGNC
Official Full Name
high density lipoprotein binding proteinprovided by HGNC
Primary source
HGNC:HGNC:4857
See related
Ensembl:ENSG00000115677 MIM:142695; AllianceGenome:HGNC:4857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBP; VGL; PRO2900
Summary
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in testis (RPKM 89.6), thyroid (RPKM 63.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HDLBP in Genome Data Viewer
Location:
2q37.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241227291..241315672, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241726284..241814658, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242166706..242255087, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17415 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57723 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242079269-242079769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12530 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242097726-242098226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242106157-242106656 Neighboring gene uncharacterized LOC105373971 Neighboring gene protein phosphatase 1 regulatory subunit 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242125644-242126166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242127362-242128046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242128047-242128730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242129664-242130164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242130165-242130665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242152515-242153074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242155713-242156244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17420 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242163435-242164395 Neighboring gene uncharacterized LOC105376810 Neighboring gene anoctamin 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242220649-242221149 Neighboring gene HDLBP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242248819-242249320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255088-242255812 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255813-242256537 Neighboring gene septin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12537 Neighboring gene uncharacterized LOC105373973 Neighboring gene Sharpr-MPRA regulatory region 5168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12538 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242386413-242387062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242407765-242408327 Neighboring gene microRNA 3133

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders. Mushtaq A, et al. J Biol Chem, 2023 Mar. PMID 36758804, Free PMC Article
  2. A jack of all trades: the RNA-binding protein vigilin. Cheng MH, et al. Wiley Interdiscip Rev RNA, 2017 Nov. PMID 28975734
  3. Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth. Yang WL, et al. Oncol Rep, 2014 May. PMID 24676454
  4. [Expression of vigilin in cell lines and human hepatocellular carcinoma]. Duan SW, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2011 Mar. PMID 21500547
  5. Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain. Vollbrandt T, et al. Int J Biochem Cell Biol, 2004 Jul. PMID 15109574

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders.
    Title: Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders.
  2. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
    Title: HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
  3. HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
    Title: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
  4. The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition.
    Title: The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition.
  5. HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
    Title: HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
  6. TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
    Title: TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
  7. Our data reveal that vigilin is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1-7 domains of vigilin and zinc-finger domains of CTCF.
    Title: Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.
  8. vigilin has been shown to bind over 700 mRNAs and has been associated with cancer progression and cardiovascular disease.
    Title: A jack of all trades: the RNA-binding protein vigilin.
  9. this study shows that vigilin (HDLBP) binds and negatively regulates MICB expression through its 5'UTR, and that vigilin downregulation in target cells leads to NK cell activation against said target cells
    Title: Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region.
  10. progressively upregulated vigilin may serve as a molecular risk marker for hepatocellular carcinoma development, and targeting vigilin may help to inhibit hepatocellular carcinoma cell growth, survival and migration.
    Title: Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated high density lipoprotein binding protein (HDLBP, Vigilin) is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ16432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables lipid binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
vigilin
Names
HDL-binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243900.3 → NP_001230829.1  vigilin isoform b

    See identical proteins and their annotated locations for NP_001230829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a downstream promoter compared to variant 1.
    Source sequence(s)
    AC104841, AI434711, AK300312, BP359370
    Consensus CDS
    CCDS58760.1
    UniProtKB/TrEMBL
    B2R5V9
    Related
    ENSP00000399139.2, ENST00000427183.6
    Conserved Domains (1) summary
    cd02394
    Location:622 → 684
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

  2. NM_001320965.3 → NP_001307894.1  vigilin isoform a

    Status: REVIEWED

    Source sequence(s)
    AC104841, AI434711, AK312335, DC400438
    Consensus CDS
    CCDS2547.1
    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Related
    ENSP00000375837.2, ENST00000391976.6
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  3. NM_001320966.3 → NP_001307895.1  vigilin isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses a downstream promoter compared to variant 1.
    Source sequence(s)
    AC104841, AI434711, AK312335, BP283713
    Consensus CDS
    CCDS2547.1
    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  4. NM_001320967.3 → NP_001307896.1  vigilin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a downstream promoter compared to variant 1.
    Source sequence(s)
    AC104841, AI434711, AK312335, BP359370, DB282620
    UniProtKB/TrEMBL
    B2R5V9
    Conserved Domains (1) summary
    cd02394
    Location:655 → 717
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

  5. NM_005336.6 → NP_005327.1  vigilin isoform a

    See identical proteins and their annotated locations for NP_005327.1

    Status: REVIEWED

    Source sequence(s)
    AC104841, KF456779
    Consensus CDS
    CCDS2547.1
    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Related
    ENSP00000312042.4, ENST00000310931.10
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  6. NM_203346.6 → NP_976221.1  vigilin isoform a

    See identical proteins and their annotated locations for NP_976221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a downstream promoter compared to variant 1.
    Source sequence(s)
    AC104841, AI434711, AK312335, BP359370, DB282620
    Consensus CDS
    CCDS2547.1
    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Related
    ENSP00000375836.1, ENST00000391975.5
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    241227291..241315672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003941.3 → XP_016859430.1  vigilin isoform X2

    UniProtKB/TrEMBL
    B2R5V9
    Conserved Domains (1) summary
    cd02394
    Location:655 → 717
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

  2. XM_011511060.4 → XP_011509362.1  vigilin isoform X1

    See identical proteins and their annotated locations for XP_011509362.1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  3. XM_011511058.4 → XP_011509360.1  vigilin isoform X1

    See identical proteins and their annotated locations for XP_011509360.1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  4. XM_024452833.2 → XP_024308601.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  5. XM_047444077.1 → XP_047300033.1  vigilin isoform X2

  6. XM_047444067.1 → XP_047300023.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  7. XM_047444073.1 → XP_047300029.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  8. XM_047444079.1 → XP_047300035.1  vigilin isoform X2

  9. XM_047444068.1 → XP_047300024.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  10. XM_047444071.1 → XP_047300027.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  11. XM_047444070.1 → XP_047300026.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  12. XM_017003942.2 → XP_016859431.1  vigilin isoform X2

    UniProtKB/TrEMBL
    B2R5V9
    Conserved Domains (1) summary
    cd02394
    Location:655 → 717
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

  13. XM_005247002.5 → XP_005247059.2  vigilin isoform X1

    See identical proteins and their annotated locations for XP_005247059.2

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Conserved Domains (15) summary
    cd02394
    Location:435 → 502
    KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22405
    Location:77 → 144
    KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22406
    Location:147 → 221
    KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22407
    Location:224 → 283
    KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22408
    Location:297 → 358
    KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22409
    Location:364 → 433
    KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22410
    Location:507 → 573
    KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22411
    Location:583 → 644
    KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22412
    Location:653 → 722
    KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22413
    Location:726 → 791
    KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22414
    Location:802 → 867
    KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22415
    Location:875 → 970
    KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22416
    Location:972 → 1049
    KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22417
    Location:1053 → 1126
    KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
    cd22418
    Location:1128 → 1196
    KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

  14. XM_047444078.1 → XP_047300034.1  vigilin isoform X2

  15. XM_047444075.1 → XP_047300031.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  16. XM_047444069.1 → XP_047300025.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  17. XM_047444076.1 → XP_047300032.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  18. XM_047444072.1 → XP_047300028.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  19. XM_047444074.1 → XP_047300030.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241726284..241814658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341627.1 → XP_054197602.1  vigilin isoform X2

  2. XM_054341615.1 → XP_054197590.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  3. XM_054341620.1 → XP_054197595.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  4. XM_054341626.1 → XP_054197601.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  5. XM_054341625.1 → XP_054197600.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  6. XM_054341629.1 → XP_054197604.1  vigilin isoform X2

  7. XM_054341628.1 → XP_054197603.1  vigilin isoform X2

  8. XM_054341613.1 → XP_054197588.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  9. XM_054341621.1 → XP_054197596.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  10. XM_054341632.1 → XP_054197607.1  vigilin isoform X2

  11. XM_054341614.1 → XP_054197589.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  12. XM_054341618.1 → XP_054197593.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  13. XM_054341630.1 → XP_054197605.1  vigilin isoform X2

  14. XM_054341617.1 → XP_054197592.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  15. XM_054341624.1 → XP_054197599.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  16. XM_054341619.1 → XP_054197594.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  17. XM_054341631.1 → XP_054197606.1  vigilin isoform X2

  18. XM_054341623.1 → XP_054197598.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  19. XM_054341616.1 → XP_054197591.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7

  20. XM_054341622.1 → XP_054197597.1  vigilin isoform X1

    UniProtKB/Swiss-Prot
    B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
    UniProtKB/TrEMBL
    A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00341.3 GenPept UniProtKB/Swiss-Prot:Q00341

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous