Bloc1s5 biogenesis of lysosomal organelles complex 1 subunit 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bloc1s5provided by RGD
Official Full Name: biogenesis of lysosomal organelles complex 1 subunit 5provided by RGD
Primary source: RGD:1306846
See related: EnsemblRapid:ENSRNOG00000016497 AllianceGenome:RGD:1306846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Muted
Summary: Predicted to be involved in several processes, including anterograde synaptic vesicle transport; endosome to melanosome transport; and melanosome transport. Predicted to act upstream of or within developmental pigmentation; otolith morphogenesis; and vesicle-mediated transport. Predicted to be located in transport vesicle. Predicted to be part of BLOC-1 complex. Predicted to be active in microvesicle. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human BLOC1S5 (biogenesis of lysosomal organelles complex 1 subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 124.6), Heart (RPKM 110.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (26377549..26402869)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (26171965..26197276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (26808193..26833257)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within developmental pigmentation	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within otolith morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pigment cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microvesicle	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: biogenesis of lysosome-related organelles complex 1 subunit 5

Names: BLOC-1 subunit 5; biogenesis of lysosomal organelles complex-1, subunit 5, muted; protein Muted homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107347.1 → NP_001100817.1 biogenesis of lysosome-related organelles complex 1 subunit 5

See identical proteins and their annotated locations for NP_001100817.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/Swiss-Prot

B2GV52

Related

ENSRNOP00000022108.4, ENSRNOT00000022108.7

Conserved Domains (1) summary

pfam14942
Location:36 → 175

Muted; Organelle biogenesis, Muted-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

26377549..26402869

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253807.5 → XP_006253869.1 biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1

Related

ENSRNOP00000105165.1, ENSRNOT00000122770.1

Conserved Domains (1) summary

pfam14942
Location:36 → 220

Muted; Organelle biogenesis, Muted-like protein
XM_063276390.1 → XP_063132460.1 biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X2