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Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306759, updated on 2-Nov-2024

Summary

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Symbol
Spock1provided by RGD
Full Name
sparc/osteonectin, cwcv and kazal like domains proteoglycan 1provided by RGD
Primary source
RGD:1311496
See related
EnsemblRapid:ENSRNOG00000012747 AllianceGenome:RGD:1311496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity; cysteine-type endopeptidase inhibitor activity; and metalloendopeptidase inhibitor activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of cell-substrate adhesion; and negative regulation of endopeptidase activity. Predicted to be located in neuromuscular junction; node of Ranvier; and sarcoplasm. Predicted to be active in extracellular space and postsynaptic density. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 245.8) and Liver (RPKM 13.7) See more
Orthologs
human mouse all
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Genomic context

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See Spock1 in Genome Data Viewer
Location:
17p14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6746892..7227034)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6741504..7221685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (7675531..7797863)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482666 Neighboring gene kelch-like family member 3 Neighboring gene microRNA 874 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120097735 Neighboring gene uncharacterized LOC134482667 Neighboring gene uncharacterized LOC120097750 Neighboring gene uncharacterized LOC108348497 Neighboring gene uncharacterized LOC120097914

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Testican-1 inhibits attachment of Neuro-2a cells. Marr HS, et al. Matrix Biol, 2003 May. PMID 12853036
  2. Expression of the proteoglycan SPOCK during mouse embryo development. Charbonnier F, et al. Mech Dev, 2000 Feb. PMID 10640720
  3. Properties of the extracellular calcium binding module of the proteoglycan testican. Kohfeldt E, et al. FEBS Lett, 1997 Sep 15. PMID 9323035
  4. Regulated expression of the proteoglycan SPOCK in the neuromuscular system. Cifuentes-Diaz C, et al. Mech Dev, 2000 Jun. PMID 10842087
  5. Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L. Bocock JP, et al. Eur J Biochem, 2003 Oct. PMID 14511383

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization to extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in node of Ranvier ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testican-1
Names
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271297.1 → NP_001258226.1  testican-1

    See identical proteins and their annotated locations for NP_001258226.1

    Status: VALIDATED

    Source sequence(s)
    BC092615, CB608950, CB713141, JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KAL9, F1M6V6
    Related
    ENSRNOP00000057901.5, ENSRNOT00000061187.5
    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:314 → 375
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:199 → 317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:198 → 304
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    6746892..7227034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276334.1 → XP_063132404.1  testican-1 isoform X1

  2. XM_063276335.1 → XP_063132405.1  testican-1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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