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rag2 recombination activating gene 2 [ Danio rerio (zebrafish) ]

Gene ID: 30658, updated on 2-Nov-2024

Summary

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Official Symbol
rag2provided by ZNC
Official Full Name
recombination activating gene 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-235
See related
Ensembl:ENSDARG00000052121 AllianceGenome:ZFIN:ZDB-GENE-990415-235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rag-2; zgc:136743
Summary
Enables sequence-specific DNA binding activity. Contributes to double-stranded DNA endonuclease activity. Acts upstream of or within T cell differentiation; immune system development; and protein-DNA complex assembly. Part of DNA recombinase complex and endodeoxyribonuclease complex. Is expressed in immune system and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rag2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (9010425..9013963, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8933357..8936895, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489329 Neighboring gene recombination activating 1 Neighboring gene intraflagellar transport associated protein Neighboring gene uncharacterized LOC137489330 Neighboring gene uncharacterized LOC108181606

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish. Pruitt MM, et al. J Vis Exp, 2017 May 4. PMID 28518092, Free PMC Article
  2. Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Liau WS, et al. Leukemia, 2017 Aug. PMID 28028313, Free PMC Article
  3. Aberrant AKT activation drives well-differentiated liposarcoma. Gutierrez A, et al. Proc Natl Acad Sci U S A, 2011 Sep 27. PMID 21930930, Free PMC Article
  4. Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia. Zhang C, et al. Haematologica, 2021 Jun 1. PMID 32414855, Free PMC Article
  5. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Jiang J, et al. Cancer Cell, 2020 Feb 10. PMID 32049046, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates.
    Title: The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates.
  2. created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund
    Title: Optimized cell transplantation using adult rag2 mutant zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC136743

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to double-stranded DNA endonuclease activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within V(D)J recombination IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in V(D)J recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic or lymphoid organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin V(D)J recombination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein-DNA complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA recombinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA recombinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of endodeoxyribonuclease complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V(D)J recombination-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131385.3 → NP_571460.2  V(D)J recombination-activating protein 2

    See identical proteins and their annotated locations for NP_571460.2

    Status: VALIDATED

    Source sequence(s)
    AL935203
    UniProtKB/Swiss-Prot
    O13034
    UniProtKB/TrEMBL
    A0A8M1PBA9, Q1RLW7
    Related
    ENSDARP00000068402.5, ENSDART00000073912.6
    Conserved Domains (3) summary
    pfam03089
    Location:51 → 386
    RAG2; Recombination activating protein 2
    pfam13341
    Location:414 → 492
    RAG2_PHD; RAG2 PHD domain
    pfam13415
    Location:91 → 145
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    9010425..9013963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13034.1 GenPept UniProtKB/Swiss-Prot:O13034

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