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Pomk protein-O-mannose kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 306549, updated on 14-Nov-2024

Summary

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Official Symbol
Pomkprovided by RGD
Official Full Name
protein-O-mannose kinaseprovided by RGD
Primary source
RGD:1310810
See related
EnsemblRapid:ENSRNOG00000014628 AllianceGenome:RGD:1310810
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sgk196; RGD1310810
Summary
Predicted to enable carbohydrate kinase activity and phosphotransferase activity, alcohol group as acceptor. Predicted to be involved in carbohydrate phosphorylation and protein O-linked glycosylation. Predicted to act upstream of or within several processes, including learning or memory; neuromuscular process; and sensory perception of pain. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A12 and muscular dystrophy-dystroglycanopathy type C12. Orthologous to human POMK (protein O-mannose kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 78.6), Brain (RPKM 76.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pomk in Genome Data Viewer
Location:
16q12.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72788842..72801122)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66085569..66101360)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (70854825..70869653)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene hook microtubule-tethering protein 3 Neighboring gene farnesyltransferase, CAAX box, subunit alpha Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 5 Neighboring gene potassium calcium-activated channel subfamily U member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC114531

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotransferase activity, alcohol group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, alcohol group as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables phosphotransferase activity, alcohol group as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein O-mannose kinase
Names
probable inactive protein kinase-like protein SgK196
protein kinase-like protein SgK196
sugen kinase 196
NP_001020054.1
XP_008769575.1
XP_038950484.1
XP_038950485.1
XP_038950486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024883.1 → NP_001020054.1  protein O-mannose kinase

    See identical proteins and their annotated locations for NP_001020054.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097466
    UniProtKB/Swiss-Prot
    Q4V8A9
    UniProtKB/TrEMBL
    A0A8I6A6B4, A6IVZ8
    Related
    ENSRNOP00000019630.4, ENSRNOT00000019630.9
    Conserved Domains (1) summary
    cl21453
    Location:104 → 194
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    72788842..72801122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094556.2 → XP_038950484.1  protein O-mannose kinase isoform X1

    UniProtKB/Swiss-Prot
    Q4V8A9
    UniProtKB/TrEMBL
    A0A8I6A6B4, A6IVZ8
    Conserved Domains (1) summary
    cl21453
    Location:104 → 194
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039094558.2 → XP_038950486.1  protein O-mannose kinase isoform X1

    UniProtKB/Swiss-Prot
    Q4V8A9
    UniProtKB/TrEMBL
    A0A8I6A6B4, A6IVZ8
    Conserved Domains (1) summary
    cl21453
    Location:104 → 194
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039094557.2 → XP_038950485.1  protein O-mannose kinase isoform X1

    UniProtKB/Swiss-Prot
    Q4V8A9
    UniProtKB/TrEMBL
    A0A8I6A6B4, A6IVZ8
    Conserved Domains (1) summary
    cl21453
    Location:104 → 194
    PKc_like; Protein Kinases, catalytic domain

  4. XM_008771353.4 → XP_008769575.1  protein O-mannose kinase isoform X1

    See identical proteins and their annotated locations for XP_008769575.1

    UniProtKB/Swiss-Prot
    Q4V8A9
    UniProtKB/TrEMBL
    A0A8I6A6B4, A6IVZ8
    Conserved Domains (1) summary
    cl21453
    Location:104 → 194
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8A9.1 GenPept UniProtKB/Swiss-Prot:Q4V8A9

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