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Sh2d4a SH2 domain containing 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 306376, updated on 17-Aug-2024

Summary

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Official Symbol
Sh2d4aprovided by RGD
Official Full Name
SH2 domain containing 4Aprovided by RGD
Primary source
RGD:1307991
See related
EnsemblRapid:ENSRNOG00000013541 AllianceGenome:RGD:1307991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatase binding activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SH2D4A (SH2 domain containing 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 288.9), Lung (RPKM 263.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (26106721..26176069, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (21339010..21409360, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (23084247..23156825, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene splicing factor YJU2-like Neighboring gene uncharacterized LOC120097455 Neighboring gene uncharacterized LOC134482490 Neighboring gene uncharacterized LOC102551750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. Patrakka J, et al. J Am Soc Nephrol, 2007 Mar. PMID 17251388
  2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012048.1 → NP_001012048.1  SH2 domain-containing protein 4A

    See identical proteins and their annotated locations for NP_001012048.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079100
    UniProtKB/Swiss-Prot
    Q6AYC8
    UniProtKB/TrEMBL
    A0A8I5ZXE8
    Related
    ENSRNOP00000018543.3, ENSRNOT00000018543.7
    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 243
    PTZ00121; MAEBL; Provisional
    cd10350
    Location:308 → 410
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    26106721..26176069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094496.2 → XP_038950424.1  SH2 domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    Q6AYC8
    UniProtKB/TrEMBL
    A0A8I5ZXE8
    Conserved Domains (2) summary
    PTZ00121
    Location:32 → 243
    PTZ00121; MAEBL; Provisional
    cd10350
    Location:308 → 410
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYC8.1 GenPept UniProtKB/Swiss-Prot:Q6AYC8

Gene LinkOut

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