bmp2b bone morphogenetic protein 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmp2bprovided by ZNC
Official Full Name: bone morphogenetic protein 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-474
See related: Ensembl:ENSDARG00000041430 AllianceGenome:ZFIN:ZDB-GENE-980526-474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: swr; bmp2; bmp-2; cb670; zbmp2; bmp2-4; zbmp-2
Summary: Enables identical protein binding activity and protein heterodimerization activity. Involved in dorsal/ventral axis specification. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; ectoderm; fin; and mesoderm. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (45893152..45899149)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (45989447..45995178)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
Title: A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
BMP heterodimers signal via distinct type I receptor class functions.
Title: BMP heterodimers signal via distinct type I receptor class functions.
Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.
Title: Hoxd13/Bmp2-mediated mechanism involved in zebrafish finfold design.
Authors revealed that the over-compensation effects of BMP signaling in MZmarcksb was achieved through a sequential up-regulation of MARCKS-family members Marcksa, Marcksl1a and Marcksl1b, and MARCKS-interacting protein Hsp70.3. They concluded that the Marcksb modulates BMP signaling through regulating the secretory pathway of Bmp2b.
Title: Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b.
Identified a population of nkx2.3+ pouch progenitors in embryos and demonstrated an essential requirement of ectodermal BMP2b for their specification. At early somite stages, nkx2.3+ cells located at lateral region of pharyngeal endoderm give rise to the pouch epithelium except a subpopulation expressing pdgfalphaa rather than nkx2.3.
Title: BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish.
BMP signalling acts early to establish broad anterior and posterior territories in the non-axial mesoderm in the formation of the zebrafish kidney.
Title: BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis.
The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
Title: Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning.
The in vitro results suggest that altered BMP2 regulatory function at rs1884302 may contribute to the etiology of sagittal nonsyndromic craniosynostosis. The in vivo results indicate that differences in regulatory activity depend on the presence of a C or T allele at rs1884302.
Title: A variant associated with sagittal nonsyndromic craniosynostosis alters the regulatory function of a non-coding element.
Vrtn binds a bmp2b regulatory sequence and acts as a repressor to inhibit its zygotic transcription.
Title: Vegetally localised Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish.
Study found that BMP-2 is negatively regulated by miR-140 during early embryogenesis and bone development in zebra fi sh.
Title: MicroRNA-140-5p impairs zebrafish embryonic bone development via targeting BMP-2.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

bmp2 (e-PCR)
- UniSTS:186933

Z22041 (e-PCR)
- UniSTS:204668

fd24a11.y1 (e-PCR)
- UniSTS:195319

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell-cell signaling involved in cell fate commitment	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal convergence	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypoblast development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locus ceruleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell migration involved in autonomic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas field specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 2b

Names: etID309839.20; swirl

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131360.2 → NP_571435.1 bone morphogenetic protein 2b precursor

See identical proteins and their annotated locations for NP_571435.1

Status: VALIDATED

Source sequence(s)

AL929237, BC114256

UniProtKB/TrEMBL

A0A8N7XIZ5, F1QGJ0, F6PC94, O93369

Related

ENSDARP00000107417.2, ENSDART00000131169.4

Conserved Domains (2) summary

pfam00688
Location:49 → 276

TGFb_propeptide; TGF-beta propeptide

cd13760
Location:311 → 411

TGF_beta_BMP2_like; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins