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Btd biotinidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 306262, updated on 2-Nov-2024

Summary

Official Symbol
Btdprovided by RGD
Official Full Name
biotinidaseprovided by RGD
Primary source
RGD:1305316
See related
EnsemblRapid:ENSRNOG00000019656 AllianceGenome:RGD:1305316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable biotinidase activity. Predicted to be involved in biotin metabolic process. Predicted to be located in apical part of cell; nucleolus; and perikaryon. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to human BTD (biotinidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 149.4), Liver (RPKM 114.9) and 9 other tissues See more
Orthologs
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Genomic context

See Btd in Genome Data Viewer
Location:
16p16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6869448..6900711)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6863068..6894345)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7758192..7791301)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC134482450 Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene ankyrin repeat domain 28 Neighboring gene mitochondrial ribosomal protein L37, pseudogene 1 Neighboring gene uncharacterized LOC120097394 Neighboring gene uncharacterized LOC102550037

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC109548

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables biotinidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biotin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within biotin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biotin metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
biotinidase
Names
biotinase
NP_001012047.1
XP_006252671.1
XP_006252672.1
XP_006252674.1
XP_006252676.1
XP_006252677.1
XP_006252680.1
XP_006252681.1
XP_006252684.1
XP_017455568.1
XP_038950381.1
XP_038950382.1
XP_038950384.1
XP_038950385.1
XP_038950386.1
XP_063131418.1
XP_063131419.1
XP_063131420.1
XP_063131422.1
XP_063131423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012047.2NP_001012047.1  biotinidase precursor

    See identical proteins and their annotated locations for NP_001012047.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6869448..6900711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275348.1XP_063131418.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2
  2. XM_006252612.3XP_006252674.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252674.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  3. XM_039094456.2XP_038950384.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  4. XM_006252609.5XP_006252671.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252671.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Related
    ENSRNOP00000109340.1, ENSRNOT00000127104.1
    Conserved Domains (2) summary
    cd07567
    Location:50353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385535
    Vanin_C; Vanin C-terminal domain
  5. XM_039094457.2XP_038950385.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  6. XM_063275350.1XP_063131420.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2
  7. XM_039094454.2XP_038950382.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  8. XM_006252619.5XP_006252681.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252681.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385535
    Vanin_C; Vanin C-terminal domain
  9. XM_017600079.3XP_017455568.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  10. XM_063275349.1XP_063131419.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2
  11. XM_006252614.3XP_006252676.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252676.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  12. XM_039094453.2XP_038950381.1  biotinidase isoform X1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385535
    Vanin_C; Vanin C-terminal domain
  13. XM_006252622.5XP_006252684.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252684.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  14. XM_006252610.4XP_006252672.1  biotinidase isoform X1

    See identical proteins and their annotated locations for XP_006252672.1

    UniProtKB/TrEMBL
    A0A140TAI2
    Conserved Domains (2) summary
    cd07567
    Location:50353
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:385535
    Vanin_C; Vanin C-terminal domain
  15. XM_006252618.4XP_006252680.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252680.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Related
    ENSRNOP00000057779.5, ENSRNOT00000061063.6
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  16. XM_006252615.4XP_006252677.1  biotinidase isoform X2

    See identical proteins and their annotated locations for XP_006252677.1

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Conserved Domains (2) summary
    cd07567
    Location:36339
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:371521
    Vanin_C; Vanin C-terminal domain
  17. XM_039094458.2XP_038950386.1  biotinidase isoform X4

    UniProtKB/TrEMBL
    A0A8I6ANH2, A6KFY3
    Related
    ENSRNOP00000100538.1, ENSRNOT00000126690.1
    Conserved Domains (2) summary
    cd07567
    Location:31289
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:321471
    Vanin_C; Vanin C-terminal domain
  18. XM_063275352.1XP_063131422.1  biotinidase isoform X2

    UniProtKB/Swiss-Prot
    Q5FVF9
    UniProtKB/TrEMBL
    A6KFY1
    Related
    ENSRNOP00000102845.1, ENSRNOT00000128281.1
  19. XM_063275353.1XP_063131423.1  biotinidase isoform X3