U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Itih1 inter-alpha trypsin inhibitor, heavy chain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306251, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Itih1provided by RGD
Official Full Name
inter-alpha trypsin inhibitor, heavy chain 1provided by RGD
Primary source
RGD:1306099
See related
EnsemblRapid:ENSRNOG00000033386 AllianceGenome:RGD:1306099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable carbohydrate binding activity and hyaluronic acid binding activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix. Orthologous to human ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 3969.5) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Itih1 in Genome Data Viewer
Location:
16p16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6128696..6142813, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6122246..6136363, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7012376..7026542, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Disdier C, et al. Int J Dev Neurosci, 2018 Apr. PMID 29079121, Free PMC Article
  2. PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. Scarchilli L, et al. J Biol Chem, 2007 Oct 12. PMID 17675295
  3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that Alterations in Itih1 expression after hypoxic-ischemic brain injury in neonatal rats
    Title: Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inter-alpha-trypsin inhibitor heavy chain H1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107291.2 → NP_001100761.2  inter-alpha-trypsin inhibitor heavy chain H1 precursor

    See identical proteins and their annotated locations for NP_001100761.2

    Status: VALIDATED

    Source sequence(s)
    BC166831
    UniProtKB/TrEMBL
    A6KG18, B2RYM3
    Related
    ENSRNOP00000103070.1, ENSRNOT00000137918.1
    Conserved Domains (4) summary
    smart00609
    Location:33 → 160
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:283 → 464
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:52 → 602
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:699 → 884
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6128696..6142813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.