ube2ib ubiquitin-conjugating enzyme E2Ib [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2ibprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2Ibprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990614-17
See related: Ensembl:ENSDARG00000007438 AllianceGenome:ZFIN:ZDB-GENE-990614-17
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ubc9; ube2i; zUbc9; ube2ia
Summary: Enables SUMO transferase activity. Acts upstream of or within several processes, including embryonic heart tube development; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; nervous system; neural crest; pectoral fin bud; and pharyngeal pouch. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (37257588..37272116, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (37213004..37227532, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate an in vivo requirement of Ubc9 for G2/M transition and/or progression through mitosis during vertebrate organogenesis.
Title: Ubc9 regulates mitosis and cell survival during zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb36g05.x1 (e-PCR)
- UniSTS:190491

fb36g05.x1 (e-PCR)
- UniSTS:190492

ubc9 (e-PCR)
- UniSTS:205473

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SUMO conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables SUMO transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aminoacyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within definitive hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-conjugating enzyme UBC9-A

Names: RING-type E3 SUMO transferase UBC9-A; SUMO-protein ligase A; ubc9.1; ubiquitin carrier protein 9-A; ubiquitin carrier protein I-A; ubiquitin-conjugating enzyme 9; ubiquitin-conjugating enzyme E2 I-A; ubiquitin-conjugating enzyme E2I; ubiquitin-protein ligase I-A

NP_571426.1

EC 2.3.2.-

XP_005174251.1

EC 2.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.