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HCRTR2 hypocretin receptor 2 [ Homo sapiens (human) ]

Gene ID: 3062, updated on 11-Apr-2024

Summary

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Official Symbol
HCRTR2provided by HGNC
Official Full Name
hypocretin receptor 2provided by HGNC
Primary source
HGNC:HGNC:4849
See related
Ensembl:ENSG00000137252 MIM:602393; AllianceGenome:HGNC:4849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX2R; OXR2; ORXR2
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
6p12.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (55106469..55284713)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (54946092..55124321)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (54971267..55147415)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986606 Neighboring gene RNA, U6 small nuclear 1023, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:54688802-54689302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:54689303-54689803 Neighboring gene Sharpr-MPRA regulatory region 2673 Neighboring gene family with sequence similarity 83 member B Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:54843646-54844146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:54874207-54874707 Neighboring gene uncharacterized LOC124901491 Neighboring gene GDNF family receptor alpha like Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase like 1 Neighboring gene Sharpr-MPRA regulatory region 3486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Hong C, et al. Nat Commun, 2021 Feb 5. PMID 33547286, Free PMC Article
  2. [Correlation of orexin-2 receptor gene polymorphisms with Alzheimer's disease]. Zhang QL, et al. Zhonghua Yi Xue Za Zhi, 2019 Apr 2. PMID 30955315
  3. Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden. Fourier C, et al. Headache, 2019 Mar. PMID 30652302, Free PMC Article
  4. C-terminus of OX2R significantly affects downstream signaling pathways. Wang C, et al. Mol Med Rep, 2017 Jul. PMID 28487995, Free PMC Article
  5. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Nishizawa D, et al. Mol Brain, 2015 Aug 20. PMID 26289589, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.
    Title: Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype.
  2. Internal and external modulation factors of the orexin system (REVIEW).
    Title: Internal and external modulation factors of the orexin system (REVIEW).
  3. Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.
    Title: Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.
  4. Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
    Title: Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
  5. Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
    Title: Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
  6. Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
    Title: Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
  7. Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.
    Title: Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.
  8. In a Swedish population, a trend for association between cluster headache and the HCRTR2 polymorphism rs3122156 was identified.
    Title: Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden.
  9. SNPs Leu72Met of the GHRL gene (rs696217), Ile408Val of the HCRTR1 gene (rs2271933) and Val308Ile of the HCRTR2 gene (rs2653349) were genotyped. None of the SNPs showed significant main or G x E effects in post-traumatic stress disorder patients.
    Title: The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.
  10. OX2R gene rs2653349 and rs2292041 polymorphisms in the Han population of Henan may be associated with Alzheimer's disease (AD), and the A allele may be a susceptible factor for AD
    Title: [Correlation of orexin-2 receptor gene polymorphisms with Alzheimer's disease].
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables orexin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orexin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian sleep/wake cycle process IEA
Inferred from Electronic Annotation
more info
  
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of circadian sleep/wake cycle, wakefulness ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
orexin receptor type 2
Names
hypocretin (orexin) receptor 2
hypocretin receptor type 2
orexin type-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012447.2 RefSeqGene

    Range
    73056..181158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384272.1 → NP_001371201.1  orexin receptor type 2

    Status: REVIEWED

    Source sequence(s)
    AL449104, AL591718
    Consensus CDS
    CCDS4956.1
    UniProtKB/Swiss-Prot
    O43614, Q5VTM0
    UniProtKB/TrEMBL
    Q548Y0, S4X0W3
    Related
    ENSP00000359899.3, ENST00000370862.4
    Conserved Domains (2) summary
    cd15208
    Location:55 → 375
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam03827
    Location:387 → 444
    Orexin_rec2; Orexin receptor type 2

  2. NM_001526.5 → NP_001517.2  orexin receptor type 2

    See identical proteins and their annotated locations for NP_001517.2

    Status: REVIEWED

    Source sequence(s)
    AL449104, AL591718
    Consensus CDS
    CCDS4956.1
    UniProtKB/Swiss-Prot
    O43614, Q5VTM0
    UniProtKB/TrEMBL
    Q548Y0, S4X0W3
    Related
    ENSP00000477548.1, ENST00000615358.4
    Conserved Domains (2) summary
    cd15208
    Location:55 → 375
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam03827
    Location:387 → 444
    Orexin_rec2; Orexin receptor type 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    55106469..55284713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010798.2 → XP_016866287.1  orexin receptor type 2 isoform X1

    UniProtKB/TrEMBL
    Q548Y0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    54946092..55124321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355266.1 → XP_054211241.1  orexin receptor type 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43614.2 GenPept UniProtKB/Swiss-Prot:O43614

Gene LinkOut

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