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Fbxl3 F-box and leucine-rich repeat protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306129, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxl3provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 3provided by RGD
Primary source
RGD:1305660
See related
EnsemblRapid:ENSRNOG00000059334 AllianceGenome:RGD:1305660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbxl3a
Summary
Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Predicted to be located in nuclear body. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 199.0), Thymus (RPKM 189.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl3 in Genome Data Viewer
Location:
15q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86321504..86341387, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79906795..79926678, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93647307..93667395, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108352966 Neighboring gene CLN5, intracellular trafficking protein Neighboring gene MYC binding protein 2 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene uncharacterized LOC108352959

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Godinho SI, et al. Science, 2007 May 11. PMID 17463252
  2. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Siepka SM, et al. Cell, 2007 Jun 1. PMID 17462724, Free PMC Article
  3. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. Anand SN, et al. J Neurosci, 2013 Apr 24. PMID 23616524, Free PMC Article
  4. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Yoo SH, et al. Cell, 2013 Feb 28. PMID 23452855, Free PMC Article
  5. Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Shi G, et al. Cell Rep, 2016 Feb 2. PMID 26776516

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 3
Names
F-box and leucine-rich repeat protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100568.1 → NP_001094038.1  F-box/LRR-repeat protein 3

    See identical proteins and their annotated locations for NP_001094038.1

    Status: VALIDATED

    Source sequence(s)
    BC092649, CB718262
    UniProtKB/TrEMBL
    A6HU89, G3V9P4
    Related
    ENSRNOP00000071266.3, ENSRNOT00000089876.3
    Conserved Domains (2) summary
    sd00034
    Location:174 → 199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:36 → 77
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    86321504..86341387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093401.2 → XP_038949329.1  F-box/LRR-repeat protein 3 isoform X1

    UniProtKB/TrEMBL
    A6HU89, G3V9P4
    Conserved Domains (2) summary
    sd00034
    Location:174 → 199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:36 → 77
    F-box-like

  2. XM_039093402.2 → XP_038949330.1  F-box/LRR-repeat protein 3 isoform X2

    UniProtKB/TrEMBL
    G3V9P4
    Related
    ENSRNOP00000100094.1, ENSRNOT00000139587.1
    Conserved Domains (2) summary
    sd00034
    Location:133 → 158
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:36 → 77
    F-box-like

  3. XM_006252442.5 → XP_006252504.1  F-box/LRR-repeat protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006252504.1

    UniProtKB/TrEMBL
    A6HU89, G3V9P4
    Related
    ENSRNOP00000104475.1, ENSRNOT00000143708.1
    Conserved Domains (2) summary
    sd00034
    Location:174 → 199
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:36 → 77
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version

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