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Spata13 spermatogenesis associated 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305938, updated on 14-Nov-2024

Summary

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Official Symbol
Spata13provided by RGD
Official Full Name
spermatogenesis associated 13provided by RGD
Primary source
RGD:1307364
See related
EnsemblRapid:ENSRNOG00000013707 AllianceGenome:RGD:1307364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Predicted to be located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. Predicted to be active in cytosol. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 175.4), Lung (RPKM 94.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spata13 in Genome Data Viewer
Location:
15p12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (38954585..39083752)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (34778479..34907645)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (40937652..41066645)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553694 Neighboring gene uncharacterized LOC120097002 Neighboring gene uncharacterized LOC120097003 Neighboring gene C1q and TNF related 9 Neighboring gene mitochondrial intermediate peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting. Evans JC, et al. J Biol Chem, 2015 Apr 17. PMID 25750125, Free PMC Article
  2. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Kawasaki Y, et al. Oncogene, 2007 Dec 6. PMID 17599059
  3. Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Sagara M, et al. Oncogene, 2009 Mar 12. PMID 19151759
  4. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Hamann MJ, et al. Mol Cell Biol, 2007 Feb. PMID 17145773, Free PMC Article
  5. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. Bristow JM, et al. J Cell Sci, 2009 Dec 15. PMID 19934221, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The guanine nucleotide exchange factor (GEF) Asef2 (Spata13) promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
    Title: The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431427.1 → NP_001418356.1  spermatogenesis-associated protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D3ZWB4

  2. NM_001431428.1 → NP_001418357.1  spermatogenesis-associated protein 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001431429.1 → NP_001418358.1  spermatogenesis-associated protein 13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6A3P0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    38954585..39083752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252113.5 → XP_006252175.1  spermatogenesis-associated protein 13 isoform X1

    Related
    ENSRNOP00000090978.2, ENSRNOT00000114572.2
    Conserved Domains (4) summary
    cd11973
    Location:727 → 798
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd01224
    Location:1021 → 1159
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:1049 → 1148
    PH; PH domain
    pfam00621
    Location:837 → 1016
    RhoGEF; RhoGEF domain

  2. XM_006252114.5 → XP_006252176.1  spermatogenesis-associated protein 13 isoform X2

    Related
    ENSRNOP00000106141.1, ENSRNOT00000126067.1
    Conserved Domains (4) summary
    cd11973
    Location:230 → 301
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd01224
    Location:524 → 662
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:552 → 651
    PH; PH domain
    pfam00621
    Location:340 → 519
    RhoGEF; RhoGEF domain

  3. XM_039093323.2 → XP_038949251.1  spermatogenesis-associated protein 13 isoform X4

    Conserved Domains (3) summary
    smart00325
    Location:84 → 263
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:268 → 406
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 43
    SH3; Src Homology 3 domain superfamily

  4. XM_006252115.5 → XP_006252177.1  spermatogenesis-associated protein 13 isoform X3

    Related
    ENSRNOP00000087721.1, ENSRNOT00000115440.2
    Conserved Domains (4) summary
    cd11973
    Location:56 → 127
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd01224
    Location:350 → 488
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:378 → 477
    PH; PH domain
    pfam00621
    Location:166 → 345
    RhoGEF; RhoGEF domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191686.1: Suppressed sequence

    Description
    NM_001191686.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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