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zp2.5 zona pellucida glycoprotein 2, tandem duplicate 5 [ Danio rerio (zebrafish) ]

Gene ID: 30593, updated on 2-Nov-2024

Summary

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Official Symbol
zp2.5provided by ZNC
Official Full Name
zona pellucida glycoprotein 2, tandem duplicate 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-090306-1
See related
Ensembl:ENSDARG00000086522 AllianceGenome:ZFIN:ZDB-GENE-090306-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp2; zgc:152728
Summary
Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to be active in collagen-containing extracellular matrix and egg coat. Is expressed in ovarian follicle stage I; ovarian follicle stage II; and ovary. Orthologous to human ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zp2.5 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54312970..54314820)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54443399..54445249)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 6 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 1 Neighboring gene uncharacterized LOC108180211 Neighboring gene placental growth factor a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mechanical analysis of chorion softening in prehatching stages of zebrafish embryos. Kim DH, et al. IEEE Trans Nanobioscience, 2006 Jun. PMID 16805104
  2. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Liu C, et al. Aquat Toxicol, 2010 Jan 21. PMID 19879662
  3. Purification and characterization of zebrafish hatching enzyme - an evolutionary aspect of the mechanism of egg envelope digestion. Sano K, et al. FEBS J, 2008 Dec. PMID 19021768
  4. Regulation of zebrafish zona pellucida gene activity in developing oocytes. Mold DE, et al. Biol Reprod, 2009 Jul. PMID 19299318
  5. Tandem-repeated Zebrafish zp3 genes possess oocyte-specific promoters and are insensitive to estrogen induction. Liu X, et al. Biol Reprod, 2006 Jun. PMID 16481590

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of zebrafish zona pellucida gene activity in developing oocytes.
    Title: Regulation of zebrafish zona pellucida gene activity in developing oocytes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC114013, MGC114014, MGC191906

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prevention of polyspermy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zona pellucida glycoprotein 2, tandem duplicate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131330.2 → NP_571405.2  zona pellucida glycoprotein 2, tandem duplicate 5 precursor

    Status: VALIDATED

    Source sequence(s)
    CU914156
    UniProtKB/TrEMBL
    A0A8M1P7K6, F1QUS3
    Related
    ENSDARP00000002544.8, ENSDART00000024598.9

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    54312970..54314820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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