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Abhd6 abhydrolase domain containing 6, acylglycerol lipase [ Rattus norvegicus (Norway rat) ]

Gene ID: 305795, updated on 17-Aug-2024

Summary

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Official Symbol
Abhd6provided by RGD
Official Full Name
abhydrolase domain containing 6, acylglycerol lipaseprovided by RGD
Primary source
RGD:1359323
See related
EnsemblRapid:ENSRNOG00000008167 AllianceGenome:RGD:1359323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable acylglycerol lipase activity and phospholipase activity. Predicted to be involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Predicted to act upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and mitochondrion. Predicted to be integral component of postsynaptic membrane. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 156.6), Kidney (RPKM 89.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19289967..19337500, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16859740..16907094, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18647903..18695133, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene PX domain containing serine/threonine kinase Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene deoxyribonuclease 1L3 Neighboring gene uncharacterized LOC103693818 Neighboring gene ATP6V1F neighbor like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat. Noguchi K, et al. Cannabis Cannabinoid Res, 2022 Apr. PMID 34468198, Free PMC Article
  2. α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Zhao S, et al. Cell Rep, 2016 Mar 29. PMID 26997277
  3. α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate. Pribasnig MA, et al. J Biol Chem, 2015 Dec 11. PMID 26491015, Free PMC Article
  4. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Thomas G, et al. Cell Rep, 2013 Oct 31. PMID 24095738, Free PMC Article
  5. Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). Navia-Paldanius D, et al. J Lipid Res, 2012 Nov. PMID 22969151, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.
    Title: Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94917

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables acylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
  
involved_in lysobisphosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lysobisphosphatidic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in monoacylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of endocannabinoid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monoacylglycerol lipase ABHD6
Names
2-arachidonoylglycerol hydrolase
abhydrolase domain-containing protein 6
NP_001007681.1
XP_006251829.1
XP_038949180.1
XP_063130269.1
XP_063130271.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007680.1 → NP_001007681.1  monoacylglycerol lipase ABHD6

    See identical proteins and their annotated locations for NP_001007681.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083826
    UniProtKB/Swiss-Prot
    Q5XI64
    UniProtKB/TrEMBL
    A0A8L2R9X1, A6K0C2
    Related
    ENSRNOP00000012271.3, ENSRNOT00000012271.6
    Conserved Domains (1) summary
    COG0596
    Location:51 → 327
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19289967..19337500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251767.5 → XP_006251829.1  monoacylglycerol lipase ABHD6 isoform X1

    See identical proteins and their annotated locations for XP_006251829.1

    UniProtKB/Swiss-Prot
    Q5XI64
    UniProtKB/TrEMBL
    A0A8L2R9X1, A6K0C2
    Conserved Domains (1) summary
    COG0596
    Location:51 → 327
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. XM_063274199.1 → XP_063130269.1  monoacylglycerol lipase ABHD6 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R9X1
    Related
    ENSRNOP00000074573.3, ENSRNOT00000080794.3

  3. XM_039093252.2 → XP_038949180.1  monoacylglycerol lipase ABHD6 isoform X4

    Conserved Domains (1) summary
    PRK14875
    Location:1 → 179
    PRK14875; acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional

  4. XM_063274201.1 → XP_063130271.1  monoacylglycerol lipase ABHD6 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI64.1 GenPept UniProtKB/Swiss-Prot:Q5XI64

Gene LinkOut

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