U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cobl cordon-bleu WH2 repeat protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 305497, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Coblprovided by RGD
Official Full Name
cordon-bleu WH2 repeat proteinprovided by RGD
Primary source
RGD:1312002
See related
EnsemblRapid:ENSRNOG00000004281 AllianceGenome:RGD:1312002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; embryonic pattern specification; and positive regulation of cell projection organization. Predicted to act upstream of or within actin cytoskeleton organization and neural tube closure. Located in cell cortex and plasma membrane. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 56.4), Liver (RPKM 52.8) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cobl in Genome Data Viewer
Location:
14q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (91041721..91274272, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86828137..87060682, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (92341949..92497169, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481784 Neighboring gene uncharacterized LOC134481783 Neighboring gene uncharacterized LOC134481785 Neighboring gene uncharacterized LOC102553003 Neighboring gene transfer RNA arginine (anticodon UCU) 6 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development. Izadi M, et al. Elife, 2021 Jul 15. PMID 34264190, Free PMC Article
  2. The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I. Schwintzer L, et al. EMBO J, 2011 Jul 1. PMID 21725280, Free PMC Article
  3. Cordon-bleu is an actin nucleation factor and controls neuronal morphology. Ahuja R, et al. Cell, 2007 Oct 19. PMID 17956734, Free PMC Article
  4. Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Gasca S, et al. Dev Genet, 1995. PMID 7586755
  5. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, et al. PLoS Biol, 2015. PMID 26334624, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
    Title: Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
  2. Cobl is an actin nucleator controlling neuronal morphology and development.
    Title: Cordon-bleu is an actin nucleation factor and controls neuronal morphology.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament network formation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament network formation ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in collateral sprouting in absence of injury IEA
Inferred from Electronic Annotation
more info
  
involved_in collateral sprouting in absence of injury ISO
Inferred from Sequence Orthology
more info
  
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
  
involved_in digestive tract development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic axis specification IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic axis specification ISO
Inferred from Sequence Orthology
more info
  
involved_in floor plate development IEA
Inferred from Electronic Annotation
more info
  
involved_in floor plate development ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in notochord development IEA
Inferred from Electronic Annotation
more info
  
involved_in notochord development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in somite specification IEA
Inferred from Electronic Annotation
more info
  
involved_in somite specification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendritic growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
is_active_in terminal web IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in terminal web ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein cordon-bleu
Names
cordon-bleu homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401101.1 → NP_001388030.1  protein cordon-bleu isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2K2Q1
    Related
    ENSRNOP00000097856.2, ENSRNOT00000105473.2

  2. NM_001401102.1 → NP_001388031.1  protein cordon-bleu isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6ASN2
    Related
    ENSRNOP00000107957.1, ENSRNOT00000135785.1

  3. NM_001401103.1 → NP_001388032.1  protein cordon-bleu isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000091350.2, ENSRNOT00000110506.2

  4. NM_001401104.1 → NP_001388033.1  protein cordon-bleu isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  5. NM_001401105.1 → NP_001388034.1  protein cordon-bleu isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZV00
    Related
    ENSRNOP00000063258.2, ENSRNOT00000064483.3

  6. NM_001401106.1 → NP_001388035.1  protein cordon-bleu isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  7. NM_001401108.1 → NP_001388037.1  protein cordon-bleu isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000102446.1, ENSRNOT00000141519.1

  8. NM_001401109.1 → NP_001388038.1  protein cordon-bleu isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  9. NM_001401112.1 → NP_001388041.1  protein cordon-bleu isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    91041721..91274272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092058.2 → XP_038947986.1  protein cordon-bleu isoform X8

    UniProtKB/TrEMBL
    A0A8I6AEB0
    Conserved Domains (4) summary
    pfam09469
    Location:152 → 228
    Cobl; Cordon-bleu ubiquitin-like domain
    cd21799
    Location:1170 → 1202
    WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21800
    Location:1216 → 1256
    WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21801
    Location:1304 → 1329
    WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

  2. XM_039092060.2 → XP_038947988.1  protein cordon-bleu isoform X9

    UniProtKB/TrEMBL
    A0A8I6AEB0
    Conserved Domains (4) summary
    pfam09469
    Location:152 → 228
    Cobl; Cordon-bleu ubiquitin-like domain
    cd21799
    Location:1138 → 1170
    WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21800
    Location:1184 → 1224
    WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21801
    Location:1272 → 1297
    WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

  3. XM_039092053.2 → XP_038947981.1  protein cordon-bleu isoform X5

    UniProtKB/TrEMBL
    A0A8I6AEB0
    Conserved Domains (4) summary
    pfam09469
    Location:152 → 228
    Cobl; Cordon-bleu ubiquitin-like domain
    cd21799
    Location:1195 → 1227
    WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21800
    Location:1241 → 1281
    WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
    cd21801
    Location:1329 → 1354
    WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

  4. XM_063273232.1 → XP_063129302.1  protein cordon-bleu isoform X10

  5. XM_063273227.1 → XP_063129297.1  protein cordon-bleu isoform X1

    Related
    ENSRNOP00000072330.3, ENSRNOT00000086154.3

  6. XM_063273229.1 → XP_063129299.1  protein cordon-bleu isoform X4

  7. XM_063273230.1 → XP_063129300.1  protein cordon-bleu isoform X6

  8. XM_063273231.1 → XP_063129301.1  protein cordon-bleu isoform X7

  9. XM_039092055.2 → XP_038947983.2  protein cordon-bleu isoform X3

  10. XM_063273228.1 → XP_063129298.1  protein cordon-bleu isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107236.1: Suppressed sequence

    Description
    NM_001107236.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZUI5.1 GenPept UniProtKB/Swiss-Prot:D3ZUI5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools