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Tlr1 toll-like receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305354, updated on 2-Nov-2024

Summary

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Official Symbol
Tlr1provided by RGD
Official Full Name
toll-like receptor 1provided by RGD
Primary source
RGD:1309975
See related
EnsemblRapid:ENSRNOG00000038722 AllianceGenome:RGD:1309975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables lipopeptide binding activity. Involved in microglial cell activation; response to bacterial lipoprotein; and toll-like receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 82.1), Kidney (RPKM 40.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tlr1 in Genome Data Viewer
Location:
14p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43737761..43750389)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43384127..43396765)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45062662..45065014)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114, member A1 Neighboring gene toll-like receptor 6 Neighboring gene toll-like receptor 10 Neighboring gene KLF transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. Adhikary S, et al. J Neurotrauma, 2011 Dec. PMID 21970496, Free PMC Article
  2. Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. Chang JS, et al. J Immunol, 2006 Mar 1. PMID 16493059
  3. Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats. Ohno K, et al. Am J Physiol Heart Circ Physiol, 2017 Dec 1. PMID 28822965
  4. Low expression of miR-1 promotes osteogenic repair of bone marrow mesenchymal stem cells by targeting TLR1. Wang JG, et al. Eur Rev Med Pharmacol Sci, 2020 Apr. PMID 32329822
  5. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. Johnson CM, et al. J Immunol, 2007 Jun 15. PMID 17548585

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low expression of miR-1 promotes osteogenic repair of bone marrow mesenchymal stem cells by targeting TLR1.
    Title: Low expression of miR-1 promotes osteogenic repair of bone marrow mesenchymal stem cells by targeting TLR1.
  2. Diabetes mellitus increases the susceptibility to acute kidney injury after acute myocardial infarction by augmented activation of renal TLR1/TLR2-mediated signaling.
    Title: Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.
  3. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
    Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
  4. toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
    Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Toll-like receptor 2 binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopeptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in microglial cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in response to bacterial lipoprotein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
toll-like receptor 1
Names
rCG56938-like
NP_001165591.1
XP_038947853.1
XP_038947854.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172120.2 → NP_001165591.1  toll-like receptor 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6JDF9
    Conserved Domains (6) summary
    smart00082
    Location:527 → 581
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:639 → 782
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:355 → 487
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:50 → 73
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:355 → 376
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72 → 127
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43737761..43750389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091926.2 → XP_038947854.1  toll-like receptor 1 isoform X1

    UniProtKB/TrEMBL
    A6JDF9, E9PTL5
    Related
    ENSRNOP00000097749.1, ENSRNOT00000112411.2
    Conserved Domains (5) summary
    PRK15370
    Location:51 → 146
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:540 → 594
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:652 → 795
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:63 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:368 → 389
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_039091925.2 → XP_038947853.1  toll-like receptor 1 isoform X1

    UniProtKB/TrEMBL
    A6JDF9, E9PTL5
    Related
    ENSRNOP00000055898.4, ENSRNOT00000059124.5
    Conserved Domains (5) summary
    PRK15370
    Location:51 → 146
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00082
    Location:540 → 594
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:652 → 795
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:63 → 86
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:368 → 389
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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