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Nsun7 NOP2/Sun RNA methyltransferase family member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305339, updated on 17-Aug-2024

Summary

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Official Symbol
Nsun7provided by RGD
Official Full Name
NOP2/Sun RNA methyltransferase family member 7provided by RGD
Primary source
RGD:1310137
See related
EnsemblRapid:ENSRNOG00000025494 AllianceGenome:RGD:1310137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310137
Summary
Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in methylation. Predicted to act upstream of or within flagellated sperm motility and sperm mitochondrion organization. Orthologous to human NSUN7 (NOP2/Sun RNA methyltransferase family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 109.0), Muscle (RPKM 102.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsun7 in Genome Data Viewer
Location:
14p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42233062..42289013, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (41878562..41935238, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43525530..43584621, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene uncharacterized LOC134481846 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S23 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. Harris T, et al. Biol Reprod, 2007 Aug. PMID 17442852
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sperm mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative methyltransferase NSUN7
Names
NOL1/NOP2/Sun domain family, member 7
NOP2/Sun domain family, member 7
Williams-Beuren syndrome critical region protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017452.2 → NP_001017452.1  putative methyltransferase NSUN7 isoform 4

    See identical proteins and their annotated locations for NP_001017452.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    Q5XIM6

  2. NM_001400916.1 → NP_001387845.1  putative methyltransferase NSUN7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5YC52, A0A8I5ZSS6
    Related
    ENSRNOP00000080300.1, ENSRNOT00000113567.2

  3. NM_001400917.1 → NP_001387846.1  putative methyltransferase NSUN7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6JDC1

  4. NM_001400918.1 → NP_001387847.1  putative methyltransferase NSUN7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6JDC1, F7EYR2
    Related
    ENSRNOP00000037949.5, ENSRNOT00000039835.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    42233062..42289013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273123.1 → XP_063129193.1  putative methyltransferase NSUN7 isoform X2

    UniProtKB/TrEMBL
    A6JDC1, F7EYR2

  2. XM_006250947.5 → XP_006251009.1  putative methyltransferase NSUN7 isoform X1

    See identical proteins and their annotated locations for XP_006251009.1

    UniProtKB/TrEMBL
    A0A8I5YC52, A0A8I5ZSS6
    Conserved Domains (1) summary
    COG0144
    Location:313 → 514
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  3. XM_063273125.1 → XP_063129195.1  putative methyltransferase NSUN7 isoform X6

  4. XM_063273124.1 → XP_063129194.1  putative methyltransferase NSUN7 isoform X6

  5. XM_039091913.2 → XP_038947841.1  putative methyltransferase NSUN7 isoform X3

    Conserved Domains (1) summary
    COG0144
    Location:313 → 448
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  6. XM_039091916.2 → XP_038947844.1  putative methyltransferase NSUN7 isoform X7

  7. XM_039091915.2 → XP_038947843.1  putative methyltransferase NSUN7 isoform X5

  8. XM_039091914.2 → XP_038947842.1  putative methyltransferase NSUN7 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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