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Enoph1 enolase-phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305177, updated on 13-Jul-2024

Summary

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Official Symbol
Enoph1provided by RGD
Official Full Name
enolase-phosphatase 1provided by RGD
Primary source
RGD:1309016
See related
AllianceGenome:RGD:1309016
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309016
Summary
Predicted to enable acireductone synthase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm and nucleus. Orthologous to human ENOPH1 (enolase-phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 179.0), Brain (RPKM 157.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Enoph1 in Genome Data Viewer
Location:
14p22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9835626..9862051, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9531336..9557797, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (11172359..11198799, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481707 Neighboring gene transmembrane protein 150C Neighboring gene uncharacterized LOC134481706 Neighboring gene uncharacterized LOC134481708 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene histone chaperone ASF1A-like Neighboring gene transcription factor BTF3-like Neighboring gene vesicle-associated membrane protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. Wang H, et al. J Mol Biol, 2005 May 13. PMID 15843022
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105720

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables acireductone synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acireductone synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acireductone synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables acireductone synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from S-adenosylmethionine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine ISO
Inferred from Sequence Orthology
more info
  
involved_in L-methionine salvage from methylthioadenosine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enolase-phosphatase E1
Names
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
E-1 enzyme
MASA homolog
NP_001009391.1
XP_017454658.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009391.1 → NP_001009391.1  enolase-phosphatase E1

    See identical proteins and their annotated locations for NP_001009391.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087697
    UniProtKB/Swiss-Prot
    Q5PPH0
    UniProtKB/TrEMBL
    A0A8I6ADH3, A6K613
    Conserved Domains (1) summary
    cd01629
    Location:12 → 231
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9835626..9862051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599169.3 → XP_017454658.1  enolase-phosphatase E1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPH0.1 GenPept UniProtKB/Swiss-Prot:Q5PPH0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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