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Ptpn14 protein tyrosine phosphatase, non-receptor type 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305064, updated on 14-Nov-2024

Summary

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Official Symbol
Ptpn14provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 14provided by RGD
Primary source
RGD:1307885
See related
EnsemblRapid:ENSRNOG00000003407 AllianceGenome:RGD:1307885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Predicted to be involved in lymphangiogenesis; negative regulation of cell population proliferation; and regulation of protein export from nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 76.4), Lung (RPKM 62.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn14 in Genome Data Viewer
Location:
13q26
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (103799473..103951708)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (101268258..101420508)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (108689916..108841593, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene wiskott-Aldrich syndrome protein homolog 1-like Neighboring gene centromere protein F Neighboring gene SET and MYND domain containing 2 Neighboring gene uncharacterized LOC134481544 Neighboring gene uncharacterized LOC134481634

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. Wadham C, et al. J Cell Sci, 2000 Sep. PMID 10934049
  2. PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Liu X, et al. Oncogene, 2013 Mar 7. PMID 22525271, Free PMC Article
  3. Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. Au AC, et al. Am J Hum Genet, 2010 Sep 10. PMID 20826270, Free PMC Article
  4. PTPN14 is required for the density-dependent control of YAP1. Wang W, et al. Genes Dev, 2012 Sep 1. PMID 22948661, Free PMC Article
  5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphangiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 14
NP_001388293.1
XP_017454326.1
XP_038946755.1
XP_038946756.1
XP_038946757.1
XP_063128460.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401364.1 → NP_001388293.1  tyrosine-protein phosphatase non-receptor type 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2K2N0
    Related
    ENSRNOP00000072308.1, ENSRNOT00000086775.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    103799473..103951708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598837.3 → XP_017454326.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N0, A0A8I5ZVY1
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    cl17171
    Location:215 → 305
    PH-like; Pleckstrin homology-like domain

  2. XM_039090828.2 → XP_038946756.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N0, A0A8I5ZVY1
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    cl17171
    Location:215 → 305
    PH-like; Pleckstrin homology-like domain

  3. XM_039090827.2 → XP_038946755.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N0, A0A8I5ZVY1
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    cl17171
    Location:215 → 305
    PH-like; Pleckstrin homology-like domain

  4. XM_063272390.1 → XP_063128460.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2N0

  5. XM_039090829.2 → XP_038946757.1  tyrosine-protein phosphatase non-receptor type 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVY1
    Conserved Domains (3) summary
    cd14599
    Location:729 → 1015
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    cl09511
    Location:1 → 51
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:46 → 136
    PH-like; Pleckstrin homology-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107200.1: Suppressed sequence

    Description
    NM_001107200.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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