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Angel2 angel homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305035, updated on 14-Nov-2024

Summary

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Official Symbol
Angel2provided by RGD
Official Full Name
angel homolog 2provided by RGD
Primary source
RGD:1305056
See related
EnsemblRapid:ENSRNOG00000003795 AllianceGenome:RGD:1305056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305056
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Predicted to be located in Cajal body and mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ANGEL2 (angel homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 86.5), Thymus (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Angel2 in Genome Data Viewer
Location:
13q27
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105041727..105060640)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102509111..102529501)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109505021..109520976)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase C1 Neighboring gene uncharacterized LOC134481611 Neighboring gene H3.3 histone B like 1 Neighboring gene vasohibin 2 Neighboring gene FLVCR choline and heme transporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Wagner E, et al. Mol Cell Biol, 2007 Mar. PMID 17178830, Free PMC Article
  2. RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. Yi X, et al. J Biol Chem, 2012 Jun 15. PMID 22547059, Free PMC Article
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein angel homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135119.3 → NP_001128591.2  protein angel homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001128591.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JGX6
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001401388.1 → NP_001388317.1  protein angel homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    F1LT13
    Related
    ENSRNOP00000005084.6, ENSRNOT00000005084.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    105041727..105060640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090824.2 → XP_038946752.1  protein angel homolog 2 isoform X3

    UniProtKB/TrEMBL
    A6JGX7
    Conserved Domains (1) summary
    cl00490
    Location:169 → 369
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_039090820.2 → XP_038946748.1  protein angel homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6JGX6
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_039090821.2 → XP_038946749.1  protein angel homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6JGX6
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_039090822.2 → XP_038946750.1  protein angel homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6JGX6
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. XM_039090823.2 → XP_038946751.1  protein angel homolog 2 isoform X1

    UniProtKB/TrEMBL
    A6JGX6
    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. XM_006250462.5 → XP_006250524.1  protein angel homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZF9
    Related
    ENSRNOP00000083532.1, ENSRNOT00000109060.2
    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  7. XM_039090825.2 → XP_038946753.1  protein angel homolog 2 isoform X4

    Conserved Domains (1) summary
    cl00490
    Location:8 → 298
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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