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Pitpnm2 phosphatidylinositol transfer protein, membrane-associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304474, updated on 10-Jul-2024

Summary

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Symbol
Pitpnm2provided by RGD
Full Name
phosphatidylinositol transfer protein, membrane-associated 2provided by RGD
Primary source
RGD:1310867
See related
EnsemblRapid:ENSRNOG00000029260 AllianceGenome:RGD:1310867
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Located in cell body. Orthologous to human PITPNM2 (phosphatidylinositol transfer protein membrane associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 89.7), Lung (RPKM 75.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pitpnm2 in Genome Data Viewer
Location:
12q15
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38008399..38140046)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32347455..32479103)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37805332..37903856)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor in rescue Neighboring gene M-phase phosphoprotein 9 Neighboring gene uncharacterized LOC134481294 Neighboring gene ADP-ribosylation factor like GTPase 6 interacting protein 4 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. Lu C, et al. J Neurosci, 1999 Sep 1. PMID 10460238, Free PMC Article
  2. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189186

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
membrane-associated phosphatidylinositol transfer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107139.1 → NP_001100609.1  membrane-associated phosphatidylinositol transfer protein 2

    See identical proteins and their annotated locations for NP_001100609.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A0A0G2JW50, A6J110
    Conserved Domains (3) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1040 → 1171
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    pfam02862
    Location:704 → 894
    DDHD; DDHD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38008399..38140046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089445.2 → XP_038945373.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  2. XM_039089453.2 → XP_038945381.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JW50
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1094 → 1225
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:991 → 1140
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 948
    DDHD; DDHD domain

  3. XM_063271306.1 → XP_063127376.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JW50, A6J110

  4. XM_063271308.1 → XP_063127378.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X5

  5. XM_063271309.1 → XP_063127379.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X6

  6. XM_039089447.2 → XP_038945375.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  7. XM_063271304.1 → XP_063127374.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JW50
    Related
    ENSRNOP00000069743.3, ENSRNOT00000091084.3

  8. XM_039089450.2 → XP_038945378.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  9. XM_039089448.2 → XP_038945376.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  10. XM_063271312.1 → XP_063127382.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JXL0, A0A9K3Y8B5, B5DF34
    Related
    ENSRNOP00000070314.2, ENSRNOT00000084587.3

  11. XM_063271311.1 → XP_063127381.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JXL0, A0A9K3Y8B5, B5DF34

  12. XM_039089449.2 → XP_038945377.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  13. XM_039089446.2 → XP_038945374.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Related
    ENSRNOP00000095932.1, ENSRNOT00000110818.2
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  14. XM_063271310.1 → XP_063127380.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JXL0, A0A9K3Y8B5, B5DF34

  15. XM_063271305.1 → XP_063127375.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JW50, F1LXD6
    Related
    ENSRNOP00000041143.5, ENSRNOT00000048528.6

  16. XM_063271303.1 → XP_063127373.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JW50

  17. XM_063271307.1 → XP_063127377.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JW50, A6J110

  18. XM_039089451.2 → XP_038945379.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW50, A0A8I6AUE0
    Conserved Domains (4) summary
    cd08889
    Location:1 → 258
    SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
    smart00775
    Location:1144 → 1275
    LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
    COG5083
    Location:1041 → 1190
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam02862
    Location:704 → 998
    DDHD; DDHD domain

  19. XM_063271313.1 → XP_063127383.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JXL0, A0A9K3Y8B5, B5DF34
Nucleotide Protein Strain
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