Cldn15 claudin 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cldn15provided by RGD
Official Full Name: claudin 15provided by RGD
Primary source: RGD:1310678
See related: EnsemblRapid:ENSRNOG00000001419 AllianceGenome:RGD:1310678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; paracellular transport; and regulation of intestinal absorption. Predicted to be located in lateral plasma membrane and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN15 (claudin 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 27.4), Kidney (RPKM 21.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25334849..25345104, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19698167..19708419, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22738198..22750392, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury.
Title: Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables paracellular tight junction channel activity	ISO Inferred from Sequence Orthology more info
enables paracellular tight junction channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in paracellular transport	ISO Inferred from Sequence Orthology more info
involved_in paracellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intestinal D-glucose absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intestinal lipid absorption	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in tight junction	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: claudin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.