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Zan zonadhesin [ Rattus norvegicus (Norway rat) ]

Gene ID: 304379, updated on 2-Nov-2024

Summary

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Official Symbol
Zanprovided by RGD
Official Full Name
zonadhesinprovided by RGD
Primary source
RGD:1305044
See related
EnsemblRapid:ENSRNOG00000067638 AllianceGenome:RGD:1305044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable extracellular matrix binding activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida and regulation of binding activity of sperm to zona pellucida. Predicted to be located in plasma membrane. Orthologous to human ZAN (zonadhesin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 21.6), Adrenal (RPKM 16.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zan in Genome Data Viewer
Location:
12q12
Exon count:
91
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24851798..24963837)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19215018..19322789)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22285377..22389008)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene erythropoietin Neighboring gene uncharacterized LOC134481172 Neighboring gene EPH receptor B4 Neighboring gene uncharacterized LOC103691283 Neighboring gene solute carrier family 12, member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. Tardif S, et al. J Biol Chem, 2010 Aug 6. PMID 20529856, Free PMC Article
  2. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. Hardy DM, et al. J Biol Chem, 1995 Nov 3. PMID 7592795

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zonadhesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107134.3 → NP_001100604.2  zonadhesin precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    Related
    ENSRNOP00000094851.2, ENSRNOT00000098130.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24851798..24963837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090053.2 → XP_038945981.1  zonadhesin isoform X2

    Conserved Domains (10) summary
    smart00832
    Location:2657 → 2728
    C8; This domain contains 8 conserved cysteine residues
    PRK10811
    Location:1117 → 1318
    rne; ribonuclease E; Reviewed
    pfam05109
    Location:472 → 834
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:4773 → 4827
    TILa; TILa domain
    cl17735
    Location:6008 → 6061
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:2461 → 2616
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:382 → 544
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5953 → 6006
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:3067 → 3125
    C8; C8 domain
    cd19941
    Location:2345 → 2398
    TIL; trypsin inhibitor-like cysteine rich domain

  2. XM_039090057.2 → XP_038945985.1  zonadhesin isoform X7

    Conserved Domains (9) summary
    smart00832
    Location:2672 → 2743
    C8; This domain contains 8 conserved cysteine residues
    PRK10811
    Location:1132 → 1333
    rne; ribonuclease E; Reviewed
    pfam12714
    Location:3919 → 3973
    TILa; TILa domain
    cl17735
    Location:2802 → 2857
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:2476 → 2631
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:397 → 559
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:2746 → 2800
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:3082 → 3140
    C8; C8 domain
    cd19941
    Location:2360 → 2413
    TIL; trypsin inhibitor-like cysteine rich domain

  3. XM_063271286.1 → XP_063127356.1  zonadhesin isoform X8

  4. XM_039090052.2 → XP_038945980.1  zonadhesin isoform X1

    Conserved Domains (10) summary
    smart00832
    Location:2672 → 2743
    C8; This domain contains 8 conserved cysteine residues
    PRK10811
    Location:1132 → 1333
    rne; ribonuclease E; Reviewed
    pfam05109
    Location:487 → 849
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:4788 → 4842
    TILa; TILa domain
    cl17735
    Location:6023 → 6076
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:2476 → 2631
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:397 → 559
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5968 → 6021
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:3082 → 3140
    C8; C8 domain
    cd19941
    Location:2360 → 2413
    TIL; trypsin inhibitor-like cysteine rich domain

  5. XM_063271283.1 → XP_063127353.1  zonadhesin isoform X4

  6. XM_063271284.1 → XP_063127354.1  zonadhesin isoform X5

  7. XM_063271285.1 → XP_063127355.1  zonadhesin isoform X6

  8. XM_039090054.2 → XP_038945982.1  zonadhesin isoform X3

    Related
    ENSRNOP00000078864.2, ENSRNOT00000115261.2
    Conserved Domains (10) summary
    smart00832
    Location:2672 → 2743
    C8; This domain contains 8 conserved cysteine residues
    PRK10811
    Location:1132 → 1333
    rne; ribonuclease E; Reviewed
    pfam05109
    Location:487 → 849
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:4788 → 4842
    TILa; TILa domain
    cl17735
    Location:6023 → 6076
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:2476 → 2631
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:397 → 559
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5968 → 6021
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:3082 → 3140
    C8; C8 domain
    cd19941
    Location:2360 → 2413
    TIL; trypsin inhibitor-like cysteine rich domain

RNA

  1. XR_010056383.1 RNA Sequence

  2. XR_010056382.1 RNA Sequence

  3. XR_005491878.2 RNA Sequence

  4. XR_005491880.2 RNA Sequence

  5. XR_005491877.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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