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Amz1 archaelysin family metallopeptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304317, updated on 2-Nov-2024

Summary

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Official Symbol
Amz1provided by RGD
Official Full Name
archaelysin family metallopeptidase 1provided by RGD
Primary source
RGD:1311314
See related
EnsemblRapid:ENSRNOG00000077699 AllianceGenome:RGD:1311314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311314
Summary
Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human AMZ1 (archaelysin family metallopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 46.3), Brain (RPKM 26.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amz1 in Genome Data Viewer
Location:
12q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19000448..19038625, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13886518..13924275, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15975211..16011238, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 11 Neighboring gene G protein subunit alpha 12 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
archaemetzincin-1
Names
archeobacterial metalloproteinase-like 1
archeobacterial metalloproteinase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047092.3 → NP_001040557.1  archaemetzincin-1

    See identical proteins and their annotated locations for NP_001040557.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    B1H214, Q400C9
    Related
    ENSRNOP00000112722.1, ENSRNOT00000124296.1
    Conserved Domains (1) summary
    cd11375
    Location:95 → 305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19000448..19038625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271271.1 → XP_063127341.1  archaemetzincin-1 isoform X2

    Related
    ENSRNOP00000107909.1, ENSRNOT00000136049.1

  2. XM_006248930.5 → XP_006248992.1  archaemetzincin-1 isoform X1

    See identical proteins and their annotated locations for XP_006248992.1

    UniProtKB/Swiss-Prot
    B1H214, Q400C9
    Conserved Domains (1) summary
    cd11375
    Location:95 → 305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

  3. XM_063271270.1 → XP_063127340.1  archaemetzincin-1 isoform X2

  4. XM_039089386.2 → XP_038945314.1  archaemetzincin-1 isoform X1

    UniProtKB/Swiss-Prot
    B1H214, Q400C9
    Conserved Domains (1) summary
    cd11375
    Location:95 → 305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

  5. XM_006248932.5 → XP_006248994.1  archaemetzincin-1 isoform X1

    See identical proteins and their annotated locations for XP_006248994.1

    UniProtKB/Swiss-Prot
    B1H214, Q400C9
    Conserved Domains (1) summary
    cd11375
    Location:95 → 305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q400C9.1 GenPept UniProtKB/Swiss-Prot:Q400C9

Gene LinkOut

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