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Bri3 brain protein I3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304284, updated on 17-Aug-2024

Summary

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Official Symbol
Bri3provided by RGD
Official Full Name
brain protein I3provided by RGD
Primary source
RGD:1309187
See related
EnsemblRapid:ENSRNOG00000001009 AllianceGenome:RGD:1309187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be located in lysosomal membrane and perinuclear region of cytoplasm. Predicted to be integral component of membrane. Orthologous to human BRI3 (brain protein I3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 246.9), Heart (RPKM 167.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bri3 in Genome Data Viewer
Location:
12p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15454673..15478319, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10341007..10364655, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12322247..12330929, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene lemur tyrosine kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-323 regulates ischemia/reperfusion injury-induced neuronal cell death by targeting BRI3. Yang L, et al. Int J Clin Exp Pathol, 2015. PMID 26617783, Free PMC Article
  2. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Wickham L, et al. J Neurochem, 2005 Jan. PMID 15606899
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-323 might regulate ischemia/reperfusion-induced rat neuronal cell death via targeting BRI3.
    Title: MicroRNA-323 regulates ischemia/reperfusion injury-induced neuronal cell death by targeting BRI3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC105711

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane protein BRI3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009604.2 → NP_001009604.1  membrane protein BRI3 isoform 1

    See identical proteins and their annotated locations for NP_001009604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q5PPK1
    Related
    ENSRNOP00000001336.4, ENSRNOT00000001336.8
    Conserved Domains (1) summary
    pfam10164
    Location:29 → 124
    DUF2367; Uncharacterized conserved protein (DUF2367)

  2. NM_001393811.1 → NP_001380740.1  membrane protein BRI3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6AW69
    Related
    ENSRNOP00000092853.1, ENSRNOT00000092487.3
    Conserved Domains (1) summary
    pfam10164
    Location:34 → 119
    DUF2367; Uncharacterized conserved protein (DUF2367)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15454673..15478319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPK1.1 GenPept UniProtKB/Swiss-Prot:Q5PPK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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