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Il10rb interleukin 10 receptor subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 304091, updated on 2-Nov-2024

Summary

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Official Symbol
Il10rbprovided by RGD
Official Full Name
interleukin 10 receptor subunit betaprovided by RGD
Primary source
RGD:1560373
See related
EnsemblRapid:ENSRNOG00000028638 AllianceGenome:RGD:1560373
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560373
Summary
Predicted to enable coreceptor activity and interleukin-10 receptor activity. Predicted to be involved in interleukin-10-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 112.5), Lung (RPKM 100.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il10rb in Genome Data Viewer
Location:
11q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44132471..44154062)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30646494..30668081)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31560301..31582457)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481055 Neighboring gene uncharacterized LOC120095615 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene uncharacterized LOC120095617 Neighboring gene uncharacterized LOC120095616 Neighboring gene uncharacterized LOC102554317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. Spencer SD, et al. J Exp Med, 1998 Feb 16. PMID 9463407, Free PMC Article
  2. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. Xu J, et al. J Pediatr Gastroenterol Nutr, 2011 Feb. PMID 21240009
  3. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor. Sivula J, et al. BMC Immunol, 2009 May 4. PMID 19409109, Free PMC Article
  4. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. Yoon SI, et al. J Biol Chem, 2006 Nov 17. PMID 16982608
  5. Biology of interleukin-10. Sabat R, et al. Cytokine Growth Factor Rev, 2010 Oct. PMID 21115385

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-10 receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-10-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-10 receptor subunit beta
Names
interleukin 10 receptor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107111.1 → NP_001100581.1  interleukin-10 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_001100581.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473989
    UniProtKB/TrEMBL
    A6JLF1, D3ZM36
    Conserved Domains (2) summary
    pfam09294
    Location:113 → 215
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:23 → 102
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    44132471..44154062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270594.1 → XP_063126664.1  interleukin-10 receptor subunit beta isoform X7

  2. XM_006248062.5 → XP_006248124.1  interleukin-10 receptor subunit beta isoform X3

    UniProtKB/TrEMBL
    D3ZM36
    Related
    ENSRNOP00000102884.1, ENSRNOT00000147658.1
    Conserved Domains (2) summary
    pfam09294
    Location:113 → 215
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:23 → 102
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_063270593.1 → XP_063126663.1  interleukin-10 receptor subunit beta isoform X6

  4. XM_063270590.1 → XP_063126660.1  interleukin-10 receptor subunit beta isoform X1

  5. XM_063270591.1 → XP_063126661.1  interleukin-10 receptor subunit beta isoform X2

    UniProtKB/TrEMBL
    A6JLF2
    Related
    ENSRNOP00000058062.5, ENSRNOT00000061345.5

  6. XM_006248063.5 → XP_006248125.1  interleukin-10 receptor subunit beta isoform X4

    UniProtKB/TrEMBL
    D3ZM36
    Related
    ENSRNOP00000110332.1, ENSRNOT00000140116.1
    Conserved Domains (2) summary
    pfam09294
    Location:92 → 194
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:2 → 81
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  7. XM_063270592.1 → XP_063126662.1  interleukin-10 receptor subunit beta isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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