Ets2 ETS proto-oncogene 2, transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ets2provided by RGD
Official Full Name: ETS proto-oncogene 2, transcription factorprovided by RGD
Primary source: RGD:1584977
See related: EnsemblRapid:ENSRNOG00000001647 AllianceGenome:RGD:1584977
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA binding activity and nuclear glucocorticoid receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human ETS2 (ETS proto-oncogene 2, transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 155.5), Kidney (RPKM 147.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (48491057..48507843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (35021536..35038322)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (36075709..36092495)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclude that variations in ETS2 abundance in hearts of adult rodents and the associated loss of cardiomyocytes contribute at least partially, to the longevity variability observed during normal aging of rats through activation of programmed necrosis
Title: Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats.
Cranial suture cells can respond to tensile forces by increasing [Ca 2+]ic, which causes CaMKII to phosphorylate Ets-2, thus altering Ets-2 binding to its downstream promoters.
Title: Tensile strain-induced Ets-2 phosphorylation by CaMKII and the homeostasis of cranial sutures.
ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs
Title: The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs.

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General gene information

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Markers

ETV2 (e-PCR)
- UniSTS:266755

AU022856 (e-PCR)
- UniSTS:160607

AU022856 (e-PCR)
- UniSTS:209252

RH139731 (e-PCR)
- UniSTS:221815

RH143332 (e-PCR)
- UniSTS:232579

RH140303 (e-PCR)
- UniSTS:222380

d11mit1 (e-PCR)
- UniSTS:120748

Ets2 (e-PCR), detects polymorphism
- UniSTS:532454

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ectodermal cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive streak formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein C-ets-2

Names: E26 avian leukemia oncogene 2, 3' domain; avian erythroblastosis virus E26 (v-ets) oncogene homolog 2; v-ets avian erythroblastosis virus E26 oncogene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107107.1 → NP_001100577.2 protein C-ets-2

See identical proteins and their annotated locations for NP_001100577.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6GB76, A6KPT9

Conserved Domains (2) summary

cd08543
Location:85 → 173

SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2

smart00413
Location:363 → 447

ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

48491057..48507843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248177.4 → XP_006248239.1 protein C-ets-2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZS11, A0A8I6GB76

Related

ENSRNOP00000079943.1, ENSRNOT00000110500.2

Conserved Domains (2) summary

cd08543
Location:109 → 197

SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2

smart00413
Location:387 → 471

ETS; erythroblast transformation specific domain