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Pigz phosphatidylinositol glycan anchor biosynthesis, class Z [ Rattus norvegicus (Norway rat) ]

Gene ID: 303872, updated on 17-Aug-2024

Summary

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Symbol
Pigzprovided by RGD
Full Name
phosphatidylinositol glycan anchor biosynthesis, class Zprovided by RGD
Primary source
RGD:1307107
See related
EnsemblRapid:ENSRNOG00000079289 AllianceGenome:RGD:1307107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pigzl1; RGD1307107
Summary
Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human PIGZ (phosphatidylinositol glycan anchor biosynthesis class Z). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 12.2), Thymus (RPKM 10.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigz in Genome Data Viewer
Location:
11q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82336821..82357743, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68831847..68851798, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72930040..72936002, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene uncharacterized LOC108352349 Neighboring gene uncharacterized LOC102549772 Neighboring gene uncharacterized LOC120095672 Neighboring gene melanotransferrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo. Taron BW, et al. J Biol Chem, 2004 Aug 20. PMID 15208306
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,2-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GPI mannosyltransferase 4
Names
GPI mannosyltransferase 4-like
phosphatidylinositol glycan, class Z
phosphatidylinositol glycan, class Z-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398770.1 → NP_001385699.1  GPI mannosyltransferase 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    Conserved Domains (1) summary
    cl21590
    Location:13 → 414
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. NM_001398771.1 → NP_001385700.1  GPI mannosyltransferase 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    Related
    ENSRNOP00000108810.1, ENSRNOT00000157345.1
    Conserved Domains (1) summary
    cl21590
    Location:13 → 414
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    82336821..82357743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270494.1 → XP_063126564.1  GPI mannosyltransferase 4 isoform X1

  2. XM_063270493.1 → XP_063126563.1  GPI mannosyltransferase 4 isoform X1

  3. XM_063270498.1 → XP_063126568.1  GPI mannosyltransferase 4 isoform X1

  4. XM_063270496.1 → XP_063126566.1  GPI mannosyltransferase 4 isoform X1

  5. XM_063270495.1 → XP_063126565.1  GPI mannosyltransferase 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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