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Tbccd1 TBCC domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303830, updated on 17-Aug-2024

Summary

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Official Symbol
Tbccd1provided by RGD
Official Full Name
TBCC domain containing 1provided by RGD
Primary source
RGD:1309604
See related
EnsemblRapid:ENSRNOG00000026458 AllianceGenome:RGD:1309604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crygs
Summary
Predicted to be involved in several processes, including maintenance of Golgi location; maintenance of centrosome location; and regulation of cell shape. Predicted to be located in cytoplasm. Predicted to be active in spindle pole centrosome. Orthologous to human TBCCD1 (TBCC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 76.1), Testes (RPKM 68.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbccd1 in Genome Data Viewer
Location:
11q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91672948..91710120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78168386..78205314)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81757963..81794367)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene alpha-2-HS-glycoprotein Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene crystallin, gamma S Neighboring gene uncharacterized LOC100911962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. Gonçalves J, et al. EMBO Rep, 2010 Mar. PMID 20168327, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108782

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in maintenance of Golgi location IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of Golgi location ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of Golgi location ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of centrosome location IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of centrosome location ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of centrosome location ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
TBCC domain-containing protein 1
Names
crystallin, gamma S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012016.1 → NP_001012016.1  TBCC domain-containing protein 1

    See identical proteins and their annotated locations for NP_001012016.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089823
    UniProtKB/Swiss-Prot
    Q5FVR8
    UniProtKB/TrEMBL
    A0A8I5ZT70
    Related
    ENSRNOP00000088290.1, ENSRNOT00000111940.2
    Conserved Domains (1) summary
    pfam07986
    Location:329 → 444
    TBCC; Tubulin binding cofactor C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91672948..91710120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248545.5 → XP_006248607.1  TBCC domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT70
    Related
    ENSRNOP00000036828.5, ENSRNOT00000038826.5
    Conserved Domains (1) summary
    pfam07986
    Location:362 → 477
    TBCC; Tubulin binding cofactor C

  2. XM_039088290.2 → XP_038944218.1  TBCC domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6AXX8
    Conserved Domains (1) summary
    cl29757
    Location:362 → 407
    TBCC; Tubulin binding cofactor C

  3. XM_039088289.2 → XP_038944217.1  TBCC domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5FVR8
    UniProtKB/TrEMBL
    A0A8I5ZT70
    Conserved Domains (1) summary
    pfam07986
    Location:329 → 444
    TBCC; Tubulin binding cofactor C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVR8.1 GenPept UniProtKB/Swiss-Prot:Q5FVR8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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