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Map3k13 mitogen-activated protein kinase kinase kinase 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303823, updated on 2-Nov-2024

Summary

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Official Symbol
Map3k13provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by RGD
Primary source
RGD:1561227
See related
EnsemblRapid:ENSRNOG00000025423 AllianceGenome:RGD:1561227
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including IkappaB kinase complex binding activity; JUN kinase kinase kinase activity; and protein homodimerization activity. Predicted to be involved in several processes, including MAPK cascade; positive regulation of cell projection organization; and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 120.1), Liver (RPKM 97.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map3k13 in Genome Data Viewer
Location:
11q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (92596436..92741717, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (79094087..79235181, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (82744391..82938357, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene lipase H Neighboring gene transmembrane protein 41a Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Neighboring gene uncharacterized LOC134481029

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma. Hao D, et al. Gut, 2021 Nov. PMID 33334899, Free PMC Article
  2. Identification and characterization of functional domains in a mixed lineage kinase LZK. Ikeda A, et al. FEBS Lett, 2001 Jan 19. PMID 11163770
  3. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. Sakuma H, et al. J Biol Chem, 1997 Nov 7. PMID 9353328
  4. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Chen M, et al. Sci Rep, 2016 Aug 11. PMID 27511108, Free PMC Article
  5. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. Ikeda A, et al. J Biochem, 2001 Dec. PMID 11726277

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables IkappaB kinase complex binding ISO
Inferred from Sequence Orthology
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 13
Names
leucine zipper-bearing kinase
NP_001014000.2
XP_017453465.1
XP_063126552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013978.2 → NP_001014000.2  mitogen-activated protein kinase kinase kinase 13

    See identical proteins and their annotated locations for NP_001014000.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473999
    UniProtKB/TrEMBL
    A6JS67, F7FMK8
    Related
    ENSRNOP00000038786.6, ENSRNOT00000035945.8
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    92596436..92741717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270482.1 → XP_063126552.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A6JS67, F7FMK8

  2. XM_017597976.3 → XP_017453465.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/TrEMBL
    A6JS67, F7FMK8
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
Nucleotide Protein Strain
Heading Accession and Version

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