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Lamp3 lysosomal-associated membrane protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303801, updated on 10-Oct-2024

Summary

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Official Symbol
Lamp3provided by RGD
Official Full Name
lysosomal-associated membrane protein 3provided by RGD
Primary source
RGD:1307928
See related
EnsemblRapid:ENSRNOG00000022792 AllianceGenome:RGD:1307928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including negative regulation of proteolysis; regulation of viral life cycle; and response to interferon-alpha. Located in alveolar lamellar body membrane. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 799.8) See more
Orthologs
human mouse all
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Genomic context

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See Lamp3 in Genome Data Viewer
Location:
11q23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94657817..94726451)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (81153491..81224643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84930965..85000694)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095700 Neighboring gene microRNA 6323 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Neighboring gene olfactory receptor family 2 subfamily AJ member 4B Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plasma membrane trafficking in alveolar type II cells. Albrecht S, et al. Cell Physiol Biochem, 2010. PMID 20054147
  2. Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer. Mine KL, et al. Nat Commun, 2013. PMID 23651994, Free PMC Article
  3. Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells. Zhou Z, et al. Virol J, 2011 Aug 3. PMID 21810281, Free PMC Article
  4. Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Salaun B, et al. Eur J Immunol, 2003 Sep. PMID 12938238
  5. Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. Dominguez-Bautista JA, et al. Eur J Cell Biol, 2015 Mar-Apr. PMID 25681212

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in alveolar lamellar body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in alveolar lamellar body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysosome-associated membrane glycoprotein 3
Names
LAMP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012015.1 → NP_001012015.1  lysosome-associated membrane glycoprotein 3 precursor

    See identical proteins and their annotated locations for NP_001012015.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083787
    UniProtKB/Swiss-Prot
    Q5XI99
    UniProtKB/TrEMBL
    A0A8I6A5E6
    Related
    ENSRNOP00000087228.1, ENSRNOT00000108731.2
    Conserved Domains (1) summary
    pfam01299
    Location:216 → 358
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    94657817..94726451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270465.1 → XP_063126535.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  2. XM_063270467.1 → XP_063126537.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  3. XM_039088271.2 → XP_038944199.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99
    UniProtKB/TrEMBL
    A0A8I6A5E6
    Related
    ENSRNOP00000038456.3, ENSRNOT00000034498.7
    Conserved Domains (1) summary
    pfam01299
    Location:216 → 358
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

  4. XM_063270462.1 → XP_063126532.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  5. XM_063270463.1 → XP_063126533.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  6. XM_063270464.1 → XP_063126534.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  7. XM_063270466.1 → XP_063126536.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  8. XM_039088272.2 → XP_038944200.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99
    UniProtKB/TrEMBL
    A0A8I6A5E6
    Conserved Domains (1) summary
    pfam01299
    Location:216 → 358
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

  9. XM_063270468.1 → XP_063126538.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99

  10. XM_039088273.2 → XP_038944201.1  lysosome-associated membrane glycoprotein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI99
    UniProtKB/TrEMBL
    A0A8I6A5E6
    Conserved Domains (1) summary
    pfam01299
    Location:216 → 358
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI99.1 GenPept UniProtKB/Swiss-Prot:Q5XI99

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