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Tlk2 tousled-like kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303592, updated on 10-Oct-2024

Summary

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Official Symbol
Tlk2provided by RGD
Official Full Name
tousled-like kinase 2provided by RGD
Primary source
RGD:1310907
See related
EnsemblRapid:ENSRNOG00000006285 AllianceGenome:RGD:1310907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to be located in intermediate filament and perinuclear region of cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 106.8), Thymus (RPKM 93.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tlk2 in Genome Data Viewer
Location:
10q32.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (90648623..90748427)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90154449..90248562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93410181..93507277)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 3 Neighboring gene U6 spliceosomal RNA Neighboring gene methyltransferase like 2 Neighboring gene cactin, spliceosome C complex subunit, pseudogene 2 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120095186 Neighboring gene cytochrome c, somatic, pseudogene 6 Neighboring gene uncharacterized LOC120095187 Neighboring gene mannose receptor, C type 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Shalom S, et al. Mol Reprod Dev, 1999 Apr. PMID 10092119
  2. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. Yamakawa A, et al. Gene, 1997 Nov 20. PMID 9427565
  3. Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. Zhang S, et al. J Biol Chem, 1999 Aug 27. PMID 10455159
  4. Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules. Yeh CH, et al. Biochem Biophys Res Commun, 2010 Sep 17. PMID 20705056
  5. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. Pilyugin M, et al. PLoS One, 2009 Dec 16. PMID 20016786, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleus localization ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 2
NP_001178581.1
XP_006247636.1
XP_006247638.1
XP_017452825.1
XP_038942061.1
XP_038942062.1
XP_038942065.1
XP_038942066.1
XP_038942067.1
XP_038942069.1
XP_063125254.1
XP_063125255.1
XP_063125256.1
XP_063125257.1
XP_063125258.1
XP_063125259.1
XP_063125260.1
XP_063125261.1
XP_063125262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191652.3 → NP_001178581.1  serine/threonine-protein kinase tousled-like 2

    See identical proteins and their annotated locations for NP_001178581.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    F1LPP2
    Related
    ENSRNOP00000062555.3, ENSRNOT00000066484.4
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    90648623..90748427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247574.5 → XP_006247636.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_006247636.1

    UniProtKB/TrEMBL
    F1LPP2
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  2. XM_039086139.2 → XP_038942067.1  serine/threonine-protein kinase tousled-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6GMB5
    Related
    ENSRNOP00000100910.1, ENSRNOT00000163614.1
    Conserved Domains (2) summary
    COG1196
    Location:112 → 409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:339 → 647
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  3. XM_039086133.2 → XP_038942061.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    UniProtKB/TrEMBL
    F1LPP2
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  4. XM_039086138.2 → XP_038942066.1  serine/threonine-protein kinase tousled-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6GMB5
    Conserved Domains (2) summary
    COG1196
    Location:112 → 409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:339 → 647
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  5. XM_039086134.2 → XP_038942062.1  serine/threonine-protein kinase tousled-like 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZZQ4, A6HJX5, F1LPP2
    Related
    ENSRNOP00000110258.1, ENSRNOT00000164499.1
    Conserved Domains (2) summary
    COG1196
    Location:174 → 471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:401 → 709
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  6. XM_063269191.1 → XP_063125261.1  serine/threonine-protein kinase tousled-like 2 isoform X12

    Related
    ENSRNOP00000088191.2, ENSRNOT00000096733.2

  7. XM_039086137.2 → XP_038942065.1  serine/threonine-protein kinase tousled-like 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GMB5
    Conserved Domains (2) summary
    COG1196
    Location:136 → 433
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:363 → 671
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  8. XM_017597336.3 → XP_017452825.1  serine/threonine-protein kinase tousled-like 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6GMB5
    Conserved Domains (2) summary
    COG1196
    Location:112 → 409
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:339 → 647
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  9. XM_063269192.1 → XP_063125262.1  serine/threonine-protein kinase tousled-like 2 isoform X14

  10. XM_063269190.1 → XP_063125260.1  serine/threonine-protein kinase tousled-like 2 isoform X9

  11. XM_063269187.1 → XP_063125257.1  serine/threonine-protein kinase tousled-like 2 isoform X5

  12. XM_063269186.1 → XP_063125256.1  serine/threonine-protein kinase tousled-like 2 isoform X3

  13. XM_063269184.1 → XP_063125254.1  serine/threonine-protein kinase tousled-like 2 isoform X1

    Related
    ENSRNOP00000084710.2, ENSRNOT00000106328.2

  14. XM_063269185.1 → XP_063125255.1  serine/threonine-protein kinase tousled-like 2 isoform X2

  15. XM_063269188.1 → XP_063125258.1  serine/threonine-protein kinase tousled-like 2 isoform X6

    Related
    ENSRNOP00000091443.2, ENSRNOT00000118444.2

  16. XM_063269189.1 → XP_063125259.1  serine/threonine-protein kinase tousled-like 2 isoform X8

  17. XM_006247576.5 → XP_006247638.1  serine/threonine-protein kinase tousled-like 2 isoform X4

    See identical proteins and their annotated locations for XP_006247638.1

    UniProtKB/TrEMBL
    F1LPP2
    Conserved Domains (2) summary
    COG1196
    Location:206 → 503
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:433 → 741
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

  18. XM_039086141.2 → XP_038942069.1  serine/threonine-protein kinase tousled-like 2 isoform X13

    UniProtKB/TrEMBL
    A0A8I6GMB5
    Related
    ENSRNOP00000099586.1, ENSRNOT00000139233.1
    Conserved Domains (2) summary
    COG1196
    Location:102 → 399
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd14041
    Location:329 → 637
    STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
Nucleotide Protein Strain
Heading Accession and Version

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