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Dvl2 dishevelled segment polarity protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303251, updated on 10-Jul-2024

Summary

Gene symbol
Dvl2
Gene description
dishevelled segment polarity protein 2
See related
EnsemblRapid:ENSRNOG00000017915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dvl-2
Expression
Biased expression in Thymus (RPKM 78.4), Lung (RPKM 61.9) and 9 other tissues See more
Orthologs
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Genomic context

See Dvl2 in Genome Data Viewer
Location:
10q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55222245..55231506)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54723356..54732823)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56609810..56619269)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
segment polarity protein dishevelled homolog DVL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172056.1NP_001165527.1  segment polarity protein dishevelled homolog DVL-2

    See identical proteins and their annotated locations for NP_001165527.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HG06, D3ZB71
    Related
    ENSRNOP00000024348.5, ENSRNOT00000024348.8
    Conserved Domains (5) summary
    smart00021
    Location:1393
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55222245..55231506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246715.5XP_006246777.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:1393
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal