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Crebrf CREB3 regulatory factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 303016, updated on 10-Oct-2024

Summary

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Official Symbol
Crebrfprovided by RGD
Official Full Name
CREB3 regulatory factorprovided by RGD
Primary source
RGD:1310862
See related
EnsemblRapid:ENSRNOG00000020769 AllianceGenome:RGD:1310862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310862
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of transport; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within maternal behavior; negative regulation of glucocorticoid mediated signaling pathway; and positive regulation of prolactin signaling pathway. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 227.9), Kidney (RPKM 225.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crebrf in Genome Data Viewer
Location:
10q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (16903607..16967450, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16399170..16479650, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (16693846..16753162, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 5 Neighboring gene BCL2 interacting protein 1 Neighboring gene uncharacterized LOC120095059 Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene ribosomal protein L26 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Liang G, et al. Mol Cell Biol, 2006 Nov. PMID 16940180, Free PMC Article
  2. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Martyn AC, et al. Mol Cell Biol, 2012 Dec. PMID 23071095, Free PMC Article
  3. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Audas TE, et al. Mol Cell Biol, 2008 Jun. PMID 18391022, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within maternal behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of glucocorticoid mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of glucocorticoid mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of prolactin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CREB3 regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277157.1 → NP_001264086.1  CREB3 regulatory factor

    See identical proteins and their annotated locations for NP_001264086.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K5W4, A6HDD8
    Related
    ENSRNOP00000073583.1, ENSRNOT00000079462.3
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    16903607..16967450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085888.2 → XP_038941816.1  CREB3 regulatory factor isoform X4

    UniProtKB/TrEMBL
    D4A811
    Related
    ENSRNOP00000104572.1, ENSRNOT00000153657.1
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  2. XM_017597237.3 → XP_017452726.1  CREB3 regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5W4, A6HDD8
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  3. XM_039085887.2 → XP_038941815.1  CREB3 regulatory factor isoform X3

    UniProtKB/TrEMBL
    A6HDD8
    Conserved Domains (1) summary
    cd14809
    Location:518 → 556
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  4. XM_063268953.1 → XP_063125023.1  CREB3 regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5W4

  5. XM_039085884.2 → XP_038941812.1  CREB3 regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5W4, A6HDD8
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

  6. XM_063268955.1 → XP_063125025.1  CREB3 regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5W4

  7. XM_063268954.1 → XP_063125024.1  CREB3 regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5W4

  8. XM_039085886.2 → XP_038941814.1  CREB3 regulatory factor isoform X2

    UniProtKB/TrEMBL
    D4A811
    Conserved Domains (1) summary
    cd14809
    Location:526 → 564
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
Nucleotide Protein Strain
Heading Accession and Version

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