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Noxo1 NADPH oxidase organizer 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302976, updated on 10-Jul-2024

Summary

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Official Symbol
Noxo1provided by RGD
Official Full Name
NADPH oxidase organizer 1provided by RGD
Primary source
RGD:1307802
See related
EnsemblRapid:ENSRNOG00000025117 AllianceGenome:RGD:1307802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in extracellular matrix disassembly and superoxide anion generation. Predicted to act upstream of or within superoxide metabolic process. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Orthologous to human NOXO1 (NADPH oxidase organizer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 27.1), Uterus (RPKM 10.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Noxo1 in Genome Data Viewer
Location:
10q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14226473..14230541)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13723253..13726008)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14062331..14066918)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene synaptogyrin 3 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene transducin (beta)-like 3 Neighboring gene ring finger protein 151 Neighboring gene small nucleolar RNA ACA64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). Yamamoto A, et al. Biochem Biophys Res Commun, 2007 Jan 12. PMID 17126813
  2. Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1. Yamamoto A, et al. FEBS J, 2013 Oct. PMID 23957209
  3. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. Bánfi B, et al. J Biol Chem, 2003 Feb 7. PMID 12473664
  4. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Gianni D, et al. Sci Signal, 2009 Sep 15. PMID 19755710, Free PMC Article
  5. Nox1-dependent reactive oxygen generation is regulated by Rac1. Cheng G, et al. J Biol Chem, 2006 Jun 30. PMID 16636067

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADPH oxidase organizer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393998.1 → NP_001380927.1  NADPH oxidase organizer 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4ACU5
    Related
    ENSRNOP00000033263.4, ENSRNOT00000029652.5
    Conserved Domains (3) summary
    cd12024
    Location:235 → 287
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3 → 122
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl17036
    Location:161 → 216
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14226473..14230541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085860.2 → XP_038941788.1  NADPH oxidase organizer 1 isoform X2

    Conserved Domains (2) summary
    cl02563
    Location:3 → 158
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl17036
    Location:197 → 252
    SH3; Src Homology 3 domain superfamily

  2. XM_039085858.2 → XP_038941786.1  NADPH oxidase organizer 1 isoform X1

    Conserved Domains (3) summary
    cd12024
    Location:271 → 323
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl02563
    Location:3 → 158
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl17036
    Location:197 → 252
    SH3; Src Homology 3 domain superfamily

  3. XM_039085863.1 → XP_038941791.1  NADPH oxidase organizer 1 isoform X3

    Conserved Domains (2) summary
    cd12024
    Location:107 → 159
    SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1
    cl17036
    Location:33 → 88
    SH3; Src Homology 3 domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106986.1: Suppressed sequence

    Description
    NM_001106986.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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