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Plp2 proteolipid protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302562, updated on 2-Nov-2024

Summary

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Official Symbol
Plp2provided by RGD
Official Full Name
proteolipid protein 2provided by RGD
Primary source
RGD:1587363
See related
AllianceGenome:RGD:1587363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
A4-LSB
Summary
Predicted to enable chemokine binding activity. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human PLP2 (proteolipid protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 163.4), Heart (RPKM 89.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plp2 in Genome Data Viewer
Location:
Xq12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17506153..17509552)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14834249..14837648)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15679254..15682653)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene G patch domain and KOW motifs Neighboring gene uncharacterized LOC134484177 Neighboring gene MAGI family member, X-linked Neighboring gene prickle planar cell polarity protein 3 Neighboring gene synaptophysin Neighboring gene uncharacterized LOC120099258 Neighboring gene calcium voltage-gated channel subunit alpha1 F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells. Lee SM, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474493
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemokine binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proteolipid protein 2
Names
Proteolipid protein 2 (intestinal membrane A4 protein)
proteolipid protein 2 (colonic epithelium-enriched)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207601.1 → NP_997484.1  proteolipid protein 2

    See identical proteins and their annotated locations for NP_997484.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061844
    UniProtKB/Swiss-Prot
    Q6P742
    UniProtKB/TrEMBL
    A6KP90
    Conserved Domains (1) summary
    pfam01284
    Location:19 → 131
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17506153..17509552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P742.1 GenPept UniProtKB/Swiss-Prot:Q6P742

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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