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Pqbp1 polyglutamine binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302557, updated on 28-Oct-2024

Summary

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Official Symbol
Pqbp1provided by RGD
Official Full Name
polyglutamine binding protein 1provided by RGD
Primary source
RGD:1549750
See related
EnsemblRapid:ENSRNOG00000007766 AllianceGenome:RGD:1549750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GTPase binding activity. Involved in positive regulation of non-motile cilium assembly. Located in centrosome and ciliary base. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 206.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pqbp1 in Genome Data Viewer
Location:
Xq12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17275445..17280018)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14603516..14608091)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15448570..15453130)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19, pseudogene 7 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene solute carrier family 35 member A2 Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Yoh SM, et al. Cell, 2015 Jun 4. PMID 26046437, Free PMC Article
  2. PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Wang Q, et al. Genes Dev, 2013 Mar 15. PMID 23512658, Free PMC Article
  3. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Ikeuchi Y, et al. Cell Rep, 2013 Sep 12. PMID 23994472, Free PMC Article
  4. The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules. Kunde SA, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933836
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to exogenous dsRNA ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyglutamine-binding protein 1
Names
PQBP-1
polyglutamine tract-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013957.3 → NP_001013979.2  polyglutamine-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Related
    ENSRNOP00000010536.3, ENSRNOT00000010536.7
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  2. NM_001434005.1 → NP_001420934.1  polyglutamine-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434006.1 → NP_001420935.1  polyglutamine-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434007.1 → NP_001420936.1  polyglutamine-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17275445..17280018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256708.5 → XP_006256770.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_006256707.4 → XP_006256769.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  3. XM_063279921.1 → XP_063135991.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KP66, G3V705

  4. XM_017601995.3 → XP_017457484.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  5. XM_063279922.1 → XP_063135992.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KP66, G3V705

  6. XM_017601996.3 → XP_017457485.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  7. XM_039099631.2 → XP_038955559.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  8. XM_017601994.3 → XP_017457483.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6PCT5
    UniProtKB/TrEMBL
    A6KP66, G3V705
    Conserved Domains (1) summary
    smart00456
    Location:47 → 78
    WW; Domain with 2 conserved Trp (W) residues

  9. XM_063279920.1 → XP_063135990.1  polyglutamine-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KP66, G3V705
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCT5.1 GenPept UniProtKB/Swiss-Prot:Q6PCT5

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