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Ap3s1 adaptor related protein complex 3 subunit sigma 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302290, updated on 28-Oct-2024

Summary

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Official Symbol
Ap3s1provided by RGD
Official Full Name
adaptor related protein complex 3 subunit sigma 1provided by RGD
Primary source
RGD:1311115
See related
EnsemblRapid:ENSRNOG00000003829 AllianceGenome:RGD:1311115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Is active in synaptic vesicle. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 101.8), Thymus (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap3s1 in Genome Data Viewer
Location:
18q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41649321..41718221)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (39462728..39531622)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40732472..40798064)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S23-like Neighboring gene cysteine dioxygenase type 1 Neighboring gene uncharacterized LOC134482941 Neighboring gene autophagy related 12 Neighboring gene uncharacterized LOC120098117 Neighboring gene protein SET-like Neighboring gene laeverin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AP-3: an adaptor-like protein complex with ubiquitous expression. Dell'Angelica EC, et al. EMBO J, 1997 Mar 3. PMID 9118953, Free PMC Article
  2. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Di Pietro SM, et al. Mol Biol Cell, 2006 Sep. PMID 16837549, Free PMC Article
  3. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376223, Free PMC Article
  4. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi to vacuole transport IEA
Inferred from Electronic Annotation
more info
  
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP-3 complex subunit sigma-1
Names
adaptor-related protein complex 3, sigma 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398640.1 → NP_001385569.1  AP-3 complex subunit sigma-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6IWX1
    Related
    ENSRNOP00000086040.2, ENSRNOT00000112095.2
    Conserved Domains (1) summary
    cd14834
    Location:1 → 146
    AP3_sigma; AP-3 complex subunit sigma

  2. NM_001398641.1 → NP_001385570.1  AP-3 complex subunit sigma-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    G3V9Y9
    Related
    ENSRNOP00000063471.2, ENSRNOT00000064116.3
    Conserved Domains (1) summary
    cd14834
    Location:1 → 146
    AP3_sigma; AP-3 complex subunit sigma

  3. NM_001398642.1 → NP_001385571.1  AP-3 complex subunit sigma-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    B2RZ62
    Related
    ENSRNOP00000087147.1, ENSRNOT00000098846.2
    Conserved Domains (1) summary
    cd14834
    Location:1 → 146
    AP3_sigma; AP-3 complex subunit sigma

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    41649321..41718221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277281.1 → XP_063133351.1  AP-3 complex subunit sigma-1 isoform X1

RNA

  1. XR_005496019.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106933.1: Suppressed sequence

    Description
    NM_001106933.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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