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ANXA2 annexin A2 [ Homo sapiens (human) ]

Gene ID: 302, updated on 5-Feb-2024

Summary

Official Symbol
ANXA2provided by HGNC
Official Full Name
annexin A2provided by HGNC
Primary source
HGNC:HGNC:537
See related
Ensembl:ENSG00000182718 MIM:151740; AllianceGenome:HGNC:537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]
Expression
Ubiquitous expression in esophagus (RPKM 162.2), skin (RPKM 128.5) and 24 other tissues See more
Orthologs
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Genomic context

See ANXA2 in Genome Data Viewer
Location:
15q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (60347151..60397986, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (58149151..58201124, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60639350..60690185, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370839 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:60577908-60578443 Neighboring gene uncharacterized LOC105370840 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:60608795-60609994 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:60659401-60660049 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:60660050-60660697 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:60663271-60664470 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:60683199-60683790 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:60684938-60686137 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:60688531-60689122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:60689123-60689714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6496 Neighboring gene ribosomal protein L36a pseudogene 44 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:60699237-60700436 Neighboring gene ribosomal protein S10 pseudogene 22 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:60770615-60771142

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Envelope transmembrane glycoprotein gp41 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
Nef nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages PubMed
gag Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of plasma membrane repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of AnxA2-p11 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PCSK9-AnxA2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PCSK9-AnxA2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex EXP
Inferred from Experiment
more info
PubMed 
located_in Schmidt-Lanterman incisure IEA
Inferred from Electronic Annotation
more info
 
located_in adherens junction HDA PubMed 
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cornified envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath adaxonal region IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of plasma membrane protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle HDA PubMed 

General protein information

Preferred Names
annexin A2
Names
annexin II
annexin-2
calpactin I heavy chain
calpactin I heavy polypeptide
calpactin-1 heavy chain
chromobindin 8
epididymis secretory protein Li 270
epididymis secretory sperm binding protein
lipocortin II
placental anticoagulant protein IV
protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002857.2NP_001002857.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001002857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, BC023990
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8
    UniProtKB/TrEMBL
    A0A024R5Z7, V9HW65
    Related
    ENSP00000411352.2, ENST00000421017.6
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
  2. NM_001002858.3NP_001002858.1  annexin A2 isoform 1

    See identical proteins and their annotated locations for NP_001002858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA661718, AC087385, BC001388, BX640598
    Consensus CDS
    CCDS32256.1
    UniProtKB/TrEMBL
    V9HW65
    Related
    ENSP00000346032.3, ENST00000332680.8
    Conserved Domains (1) summary
    pfam00191
    Location:127192
    Annexin; Annexin
  3. NM_001136015.3NP_001129487.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_001129487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AA661718, BC093056
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8
    UniProtKB/TrEMBL
    A0A024R5Z7, V9HW65
    Related
    ENSP00000379342.3, ENST00000396024.7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
  4. NM_004039.3NP_004030.1  annexin A2 isoform 2

    See identical proteins and their annotated locations for NP_004030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AW087150, BC015834, D00017
    Consensus CDS
    CCDS10175.1
    UniProtKB/Swiss-Prot
    P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8
    UniProtKB/TrEMBL
    A0A024R5Z7, V9HW65
    Related
    ENSP00000387545.3, ENST00000451270.7
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    60347151..60397986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432407.1XP_047288363.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  2. XM_047432405.1XP_047288361.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  3. XM_017022092.2XP_016877581.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
    Related
    ENSP00000453869.2, ENST00000559113.6
    Conserved Domains (1) summary
    pfam00191
    Location:152217
    Annexin
  4. XM_047432406.1XP_047288362.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  5. XM_047432404.1XP_047288360.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  6. XM_047432402.1XP_047288358.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  7. XM_047432403.1XP_047288359.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  8. XM_047432401.1XP_047288357.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    58149151..58201124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377757.1XP_054233732.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  2. XM_054377754.1XP_054233729.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  3. XM_054377756.1XP_054233731.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  4. XM_054377755.1XP_054233730.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  5. XM_054377753.1XP_054233728.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  6. XM_054377751.1XP_054233726.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  7. XM_054377752.1XP_054233727.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52
  8. XM_054377750.1XP_054233725.1  annexin A2 isoform X1

    UniProtKB/TrEMBL
    B3KRQ1, H0YL33, H0YN52