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Dtymk deoxythymidylate kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 301622, updated on 2-Nov-2024

Summary

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Official Symbol
Dtymkprovided by RGD
Official Full Name
deoxythymidylate kinaseprovided by RGD
Primary source
RGD:1309614
See related
EnsemblRapid:ENSRNOG00000018904 AllianceGenome:RGD:1309614
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Involved in several processes, including pyrimidine deoxyribonucleotide biosynthetic process; response to cadmium ion; and response to estrogen. Located in mitochondrial matrix. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 223.9), Spleen (RPKM 176.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtymk in Genome Data Viewer
Location:
9q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101762899..101771733, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94315552..94324386, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100921565..100930399, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene inhibitor of growth family, member 5 Neighboring gene D-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat. Thomson MJ, et al. Cancer Res, 1973 Feb. PMID 4347462
  2. Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats. Cihák A. Chem Biol Interact, 1979 May. PMID 223769
  3. Relationship between 5'-nucleotidase, adenosine deaminase, AMP deaminase, ATP-(Mg2+)-ase activities and dTMP kinase activity in rat liver mitochondria. Greger J, et al. Enzyme, 1979. PMID 220041
  4. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs. Rylova SN, et al. Biochem Pharmacol, 2005 Mar 15. PMID 15748706
  5. Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. Cummins RR, et al. Cancer Res, 1980 Apr. PMID 6244089

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thymidylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dTDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dTDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTTP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myoblast differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within nucleoside monophosphate phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in thymidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thymidylate kinase
NP_001100395.1
XP_006245581.1
XP_008765585.1
XP_038939353.1
XP_063123113.1
XP_063123114.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106925.1 → NP_001100395.1  thymidylate kinase

    See identical proteins and their annotated locations for NP_001100395.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473997
    UniProtKB/TrEMBL
    A6JR35
    Conserved Domains (2) summary
    PLN02924
    Location:5 → 211
    PLN02924; thymidylate kinase
    pfam02223
    Location:11 → 191
    Thymidylate_kin; Thymidylate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    101762899..101771733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245519.5 → XP_006245581.1  thymidylate kinase isoform X1

    Conserved Domains (2) summary
    PLN02924
    Location:5 → 187
    PLN02924; thymidylate kinase
    pfam02223
    Location:11 → 167
    Thymidylate_kin; Thymidylate kinase

  2. XM_039083425.2 → XP_038939353.1  thymidylate kinase isoform X4

    Conserved Domains (1) summary
    cl17190
    Location:5 → 154
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_008767363.4 → XP_008765585.1  thymidylate kinase isoform X3

    Conserved Domains (1) summary
    PLN02924
    Location:5 → 178
    PLN02924; thymidylate kinase

  4. XM_063267044.1 → XP_063123114.1  thymidylate kinase isoform X5

    UniProtKB/TrEMBL
    A6JR36

  5. XM_063267043.1 → XP_063123113.1  thymidylate kinase isoform X2

RNA

  1. XR_005488878.2 RNA Sequence

    Related
    ENSRNOT00000085029.3
Nucleotide Protein Strain
Heading Accession and Version

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