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Mff mitochondrial fission factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 301563, updated on 10-Oct-2024

Summary

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Symbol
Mffprovided by RGD
Full Name
mitochondrial fission factorprovided by RGD
Primary source
RGD:1310230
See related
EnsemblRapid:ENSRNOG00000015428 AllianceGenome:RGD:1310230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310230
Summary
Enables GTPase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of cellular component organization. Located in synaptic vesicle. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Used to study transient cerebral ischemia. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 645.3), Muscle (RPKM 505.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mff in Genome Data Viewer
Location:
9q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91455931..91484171)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84007798..84036039)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88490280..88518517)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094721 Neighboring gene collagen type IV alpha 4 chain Neighboring gene collagen type IV alpha 3 chain Neighboring gene uncharacterized LOC120094722 Neighboring gene small cysteine and glycine repeat-containing protein 6-like Neighboring gene transmembrane 4 L six family member 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Zhang XM, et al. Neurochem Int, 2015 Nov. PMID 26116440
  2. miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor. Long B, et al. Free Radic Biol Med, 2013 Dec. PMID 23867156, Free PMC Article
  3. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Lee J, et al. Endocrinology, 2018 Sep 1. PMID 30059978, Free PMC Article
  4. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Gandre-Babbe S, et al. Mol Biol Cell, 2008 Jun. PMID 18353969, Free PMC Article
  5. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, et al. Nat Cell Biol, 2013 Jul. PMID 23792689, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC112646

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome fission IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial fission factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039015.2 → NP_001034104.1  mitochondrial fission factor isoform 2

    See identical proteins and their annotated locations for NP_001034104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC098682, FN804971, JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q4KM98
    UniProtKB/TrEMBL
    A6JWA8
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 218
    Miff; Mitochondrial and peroxisomal fission factor Mff

  2. NM_001271284.1 → NP_001258213.1  mitochondrial fission factor isoform 1

    See identical proteins and their annotated locations for NP_001258213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC098682, FM107137, FN804971, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K8F3, A0A0G2KAL9, A6JWA5
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 291
    Miff; Mitochondrial and peroxisomal fission factor Mff

  3. NM_001276401.1 → NP_001263330.1  mitochondrial fission factor isoform 3

    See identical proteins and their annotated locations for NP_001263330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon in the 5' coding region, and lacks two in-frame exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter than isoform 1 and has a distinct, longer N-terminus.
    Source sequence(s)
    BC098682, FN804971, JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0H2UHM6
    Related
    ENSRNOP00000020705.3, ENSRNOT00000020705.7
    Conserved Domains (1) summary
    pfam05644
    Location:27 → 244
    Miff; Mitochondrial and peroxisomal fission factor Mff

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    91455931..91484171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245195.3 → XP_006245257.2  mitochondrial fission factor isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAL9, A0A8I6A6Z1
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 327
    Miff; Mitochondrial and peroxisomal fission factor Mff

  2. XM_006245197.4 → XP_006245259.2  mitochondrial fission factor isoform X2

    UniProtKB/TrEMBL
    A0A0G2KAL9, A0A8I5ZW06

  3. XM_063267011.1 → XP_063123081.1  mitochondrial fission factor isoform X4

  4. XM_039083388.2 → XP_038939316.1  mitochondrial fission factor isoform X6

    UniProtKB/TrEMBL
    A0A0G2KAL9
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 288
    Miff; Mitochondrial and peroxisomal fission factor Mff

  5. XM_039083389.2 → XP_038939317.1  mitochondrial fission factor isoform X7

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 277
    Miff; Mitochondrial and peroxisomal fission factor Mff

  6. XM_039083392.2 → XP_038939320.1  mitochondrial fission factor isoform X14

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 257
    Miff; Mitochondrial and peroxisomal fission factor Mff

  7. XM_006245201.3 → XP_006245263.2  mitochondrial fission factor isoform X8

  8. XM_006245205.4 → XP_006245267.2  mitochondrial fission factor isoform X11

  9. XM_006245208.4 → XP_006245270.2  mitochondrial fission factor isoform X18

    UniProtKB/TrEMBL
    A0A8I6AEV1
    Related
    ENSRNOP00000080210.2, ENSRNOT00000117981.2

  10. XM_006245198.4 → XP_006245260.2  mitochondrial fission factor isoform X3

    UniProtKB/TrEMBL
    A0A0G2KAL9

  11. XM_006245200.4 → XP_006245262.2  mitochondrial fission factor isoform X5

    UniProtKB/TrEMBL
    A0A0G2K8F3, A0A0G2KAL9, A6JWA5
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 291
    Miff; Mitochondrial and peroxisomal fission factor Mff

  12. XM_006245204.4 → XP_006245266.2  mitochondrial fission factor isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZSJ8, A6JWA6
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 271
    Miff; Mitochondrial and peroxisomal fission factor Mff

  13. XM_039083391.2 → XP_038939319.1  mitochondrial fission factor isoform X12

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 263
    Miff; Mitochondrial and peroxisomal fission factor Mff

  14. XM_039083393.2 → XP_038939321.1  mitochondrial fission factor isoform X15

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 252
    Miff; Mitochondrial and peroxisomal fission factor Mff

  15. XM_039083398.2 → XP_038939326.1  mitochondrial fission factor isoform X21

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 232
    Miff; Mitochondrial and peroxisomal fission factor Mff

  16. XM_039083395.2 → XP_038939323.1  mitochondrial fission factor isoform X16

    Conserved Domains (1) summary
    pfam05644
    Location:1 → 249
    Miff; Mitochondrial and peroxisomal fission factor Mff

  17. XM_006245209.4 → XP_006245271.2  mitochondrial fission factor isoform X19

    UniProtKB/TrEMBL
    A0A140TAC2, A6JWA7
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 238
    Miff; Mitochondrial and peroxisomal fission factor Mff

  18. XM_006245211.4 → XP_006245273.2  mitochondrial fission factor isoform X22

    UniProtKB/Swiss-Prot
    Q4KM98
    UniProtKB/TrEMBL
    A6JWA8
    Conserved Domains (1) summary
    pfam05644
    Location:1 → 218
    Miff; Mitochondrial and peroxisomal fission factor Mff

  19. XM_063267019.1 → XP_063123089.1  mitochondrial fission factor isoform X25

  20. XM_063267014.1 → XP_063123084.1  mitochondrial fission factor isoform X10

    UniProtKB/TrEMBL
    A0A0G2K2M2
    Related
    ENSRNOP00000072300.1, ENSRNOT00000089142.3

  21. XM_006245206.3 → XP_006245268.1  mitochondrial fission factor isoform X13

    See identical proteins and their annotated locations for XP_006245268.1

    UniProtKB/TrEMBL
    A0A0G2KAL9
    Related
    ENSRNOP00000081902.2, ENSRNOT00000096027.2
    Conserved Domains (1) summary
    pfam05644
    Location:27 → 342
    Miff; Mitochondrial and peroxisomal fission factor Mff

  22. XM_063267015.1 → XP_063123085.1  mitochondrial fission factor isoform X17

    Related
    ENSRNOP00000074586.2, ENSRNOT00000077859.3

  23. XM_039083397.2 → XP_038939325.1  mitochondrial fission factor isoform X20

    UniProtKB/TrEMBL
    A0A0G2KAL9
    Conserved Domains (1) summary
    pfam05644
    Location:27 → 317
    Miff; Mitochondrial and peroxisomal fission factor Mff

  24. XM_063267017.1 → XP_063123087.1  mitochondrial fission factor isoform X23

    Related
    ENSRNOP00000089302.2, ENSRNOT00000100485.2

  25. XM_063267016.1 → XP_063123086.1  mitochondrial fission factor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6Z1

  26. XM_063267018.1 → XP_063123088.1  mitochondrial fission factor isoform X24

    UniProtKB/TrEMBL
    A0A8I6ADD2, A6JWA4
    Related
    ENSRNOP00000091256.1, ENSRNOT00000107482.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM98.1 GenPept UniProtKB/Swiss-Prot:Q4KM98

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