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Sgpp2 sphingosine-1-phosphate phosphatase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301543, updated on 2-Nov-2024

Summary

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Official Symbol
Sgpp2provided by RGD
Official Full Name
sphingosine-1-phosphate phosphatase 2provided by RGD
Primary source
RGD:1565739
See related
EnsemblRapid:ENSRNOG00000069992 AllianceGenome:RGD:1565739
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565739
Summary
Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; regulation of type B pancreatic cell proliferation; and sphingosine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 81.1), Brain (RPKM 56.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sgpp2 in Genome Data Viewer
Location:
9q33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (87211155..87331787)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (79762658..79884665)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (84203094..84321269)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RING finger protein 223-like Neighboring gene U6 spliceosomal RNA Neighboring gene phenylalanyl-tRNA synthetase subunit beta Neighboring gene uncharacterized LOC134480390 Neighboring gene monoacylglycerol O-acyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. Ogawa C, et al. J Biol Chem, 2003 Jan 10. PMID 12411432
  2. Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. Taguchi Y, et al. J Biol Chem, 2016 Jun 3. PMID 27059959, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sphingosine-1-phosphate phosphatase 2
Names
sphingosine-1-phosphate phosphotase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191811.1 → NP_001178740.1  sphingosine-1-phosphate phosphatase 2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AGX4
    Related
    ENSRNOP00000105259.1, ENSRNOT00000146930.1
    Conserved Domains (2) summary
    COG0671
    Location:40 → 191
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03388
    Location:39 → 188
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    87211155..87331787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083380.2 → XP_038939308.1  sphingosine-1-phosphate phosphatase 2 isoform X1

    Conserved Domains (1) summary
    cd03388
    Location:1 → 105
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

  2. XM_063266995.1 → XP_063123065.1  sphingosine-1-phosphate phosphatase 2 isoform X2

  3. XM_039083382.2 → XP_038939310.1  sphingosine-1-phosphate phosphatase 2 isoform X2

    Conserved Domains (1) summary
    cd03388
    Location:39 → 171
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

  4. XM_039083381.2 → XP_038939309.1  sphingosine-1-phosphate phosphatase 2 isoform X1

    Conserved Domains (1) summary
    cd03388
    Location:1 → 105
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
Nucleotide Protein Strain
Heading Accession and Version

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