Arpc2 actin related protein 2/3 complex, subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arpc2provided by RGD
Official Full Name: actin related protein 2/3 complex, subunit 2provided by RGD
Primary source: RGD:1305848
See related: EnsemblRapid:ENSRNOG00000014289 AllianceGenome:RGD:1305848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p34Arc
Summary: Enables several functions, including AP-1 adaptor complex binding activity; ATPase binding activity; and Arp2/3 complex binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Located in several cellular components, including actin cytoskeleton; dendrite; and distal axon. Part of filamentous actin. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of silicosis. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 1025.8), Thymus (RPKM 929.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83269884..83300610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (75820782..75851471)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81518163..81548871)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nox1 mediates H2O2-induced ARPC2 expression.
Title: Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration.
GTP-bound Arf1 regulates inhibition of Arp2/3-mediated actin polymerization by PICK1.
Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.
Exo70 functions as a kinetic activator of the Arp2/3 complex that promotes actin filament nucleation and branching.
Title: Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.
Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
Title: Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
Title: Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139221 (e-PCR)
- UniSTS:221307

BF397552 (e-PCR)
- UniSTS:246226

BE110216 (e-PCR)
- UniSTS:245206

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AP-1 adaptor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables Arp2/3 complex binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to rapamycin	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of barbed-end actin filament capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to silicon dioxide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament branch point	IDA Inferred from Direct Assay more info	PubMed
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in concave side of sperm head	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in muscle cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in muscle cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in peripheral region of growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome core	IDA Inferred from Direct Assay more info	PubMed
located_in podosome ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in ventral surface of cell	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 2

Names: arp2/3 complex 34 kDa subunit; p34-ARC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106919.2 → NP_001100389.1 actin-related protein 2/3 complex subunit 2 isoform 1

See identical proteins and their annotated locations for NP_001100389.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0G2K185, A0A0H2UHL5, A6JVT0

Related

ENSRNOP00000019265.6, ENSRNOT00000019265.8

Conserved Domains (1) summary

pfam04045
Location:57 → 284

P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
NM_001431956.1 → NP_001418885.1 actin-related protein 2/3 complex subunit 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0H2UHL5, A6JVT0
NM_001431957.1 → NP_001418886.1 actin-related protein 2/3 complex subunit 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_001431958.1 → NP_001418887.1 actin-related protein 2/3 complex subunit 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009