Crygb crystallin, gamma B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crygbprovided by RGD
Official Full Name: crystallin, gamma Bprovided by RGD
Primary source: RGD:1584991
See related: EnsemblRapid:ENSRNOG00000032926 AllianceGenome:RGD:1584991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Len; Cryg2
Summary: Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in cataract 39 multiple types. Orthologous to human CRYGB (crystallin gamma B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 6.0), Brain (RPKM 4.7) and 3 other tissues See more
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Genomic context

Location:: 9q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (73955204..73957264, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (66461460..66463520, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (71796204..71798265, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

Crygb (e-PCR), detects polymorphism
- UniSTS:141407

UniSTS:259203 (e-PCR)
- UniSTS:259203

Crygb (e-PCR), detects polymorphism
- UniSTS:259203

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of eye lens	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of eye lens	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within eye development	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in lens development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens fiber cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens fiber cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-crystallin B

Names: CRY-gamma-B; crystallin, gamma polypeptide 2; gamma-B-crystallin; gamma-crystallin 1-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.