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Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301363, updated on 6-Jun-2024

Summary

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Official Symbol
Map4k4provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by RGD
Primary source
RGD:1305322
See related
Ensembl:ENSRNOG00000014013 AllianceGenome:RGD:1305322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; kinase activity; and microtubule binding activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and negative regulation of neuron projection regeneration. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 458.5), Lung (RPKM 271.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map4k4 in Genome Data Viewer
Location:
9q22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (49696573..49822353)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42200708..42326708)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (46657444..46782545)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094674 Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 2 Neighboring gene interleukin 1 receptor type 2 Neighboring gene uncharacterized LOC120094675

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Construction and validation of a novel prognostic signature of microRNAs in lung adenocarcinoma. Li W, et al. PeerJ, 2021. PMID 33510968, Free PMC Article
  2. Role of microRNA-141 in colorectal cancer with lymph node metastasis. Feng L, et al. Exp Ther Med, 2016 Nov. PMID 27882171, Free PMC Article
  3. Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4. Yang J, et al. Biomed Pharmacother, 2022 May. PMID 35303564
  4. MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance. Gao X, et al. Mol Oncol, 2017 Jun. PMID 28306189, Free PMC Article
  5. MAP4K4 promotes epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma. Feng XJ, et al. Tumour Biol, 2016 Aug. PMID 27010469

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4.
    Title: Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia/reperfusion via targeting MAP4K4.
  2. NIK is the first kinase shown to phosphorylate and increase the activity of the Arp2/3 complex.
    Title: The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit.
  3. Results identify MAP4K4 as a key upstream mediator of TNF-alpha action on the beta cell, preventing tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.
    Title: Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables creatine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ARF protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of focal adhesion disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
NP_001100374.2
NP_001388925.1
XP_008765225.2
XP_008765233.2
XP_008765236.2
XP_017451831.1
XP_017451832.1
XP_038939154.1
XP_038939156.1
XP_038939159.1
XP_038939161.1
XP_038939162.1
XP_038939163.1
XP_038939166.1
XP_038939167.1
XP_038939168.1
XP_038939170.1
XP_038939171.1
XP_063122965.1
XP_063122966.1
XP_063122967.1
XP_063122968.1
XP_063122969.1
XP_063122970.1
XP_063122971.1
XP_063122972.1
XP_063122974.1
XP_063122975.1
XP_063122976.1
XP_063122977.1
XP_063122978.1
XP_063122979.1
XP_063122981.1
XP_063122982.1
XP_063122983.1
XP_063122984.1
XP_063122985.1
XP_063122986.1
XP_063122987.1
XP_063122988.1
XP_063122989.1
XP_063122990.1
XP_063122991.1
XP_063122992.1
XP_063122993.1
XP_063122994.1
XP_063122995.1
XP_063122996.1
XP_063122997.1
XP_063122998.1
XP_063122999.1
XP_063123000.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106904.2 → NP_001100374.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6INM6
    Related
    ENSRNOP00000019180.7, ENSRNOT00000019180.7

  2. NM_001401996.1 → NP_001388925.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZL09, A0A8I6ADP3
    Related
    ENSRNOP00000092452.1, ENSRNOT00000102137.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    49696573..49822353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266904.1 → XP_063122974.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  2. XM_063266895.1 → XP_063122965.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  3. XM_063266899.1 → XP_063122969.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZL09

  4. XM_008767003.4 → XP_008765225.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  5. XM_063266896.1 → XP_063122966.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  6. XM_063266911.1 → XP_063122981.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

    UniProtKB/TrEMBL
    A6INM6

  7. XM_063266898.1 → XP_063122968.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZL09

  8. XM_063266906.1 → XP_063122976.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  9. XM_063266902.1 → XP_063122972.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  10. XM_039083240.2 → XP_038939168.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

    UniProtKB/TrEMBL
    A6INM6
    Conserved Domains (2) summary
    smart00036
    Location:912 → 1218
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  11. XM_063266908.1 → XP_063122978.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZL09

  12. XM_063266901.1 → XP_063122971.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  13. XM_063266905.1 → XP_063122975.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  14. XM_063266897.1 → XP_063122967.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  15. XM_039083231.2 → XP_038939159.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZLV4
    Related
    ENSRNOP00000092349.1
    Conserved Domains (2) summary
    smart00036
    Location:984 → 1290
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  16. XM_063266907.1 → XP_063122977.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZL09

  17. XM_039083235.2 → XP_038939163.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

    UniProtKB/TrEMBL
    A0A8I5ZL09
    Conserved Domains (2) summary
    smart00036
    Location:966 → 1264
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  18. XM_063266917.1 → XP_063122987.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

    UniProtKB/TrEMBL
    A0A8I5ZL09

  19. XM_063266909.1 → XP_063122979.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZL09

  20. XM_063266930.1 → XP_063123000.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X50

    UniProtKB/TrEMBL
    A6INM6

  21. XM_039083226.2 → XP_038939154.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K7W4, A0A8I5ZLV4
    Related
    ENSRNOP00000074373.2
    Conserved Domains (2) summary
    smart00036
    Location:1061 → 1359
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  22. XM_017596343.3 → XP_017451832.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  23. XM_063266924.1 → XP_063122994.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

    UniProtKB/TrEMBL
    A6INM6

  24. XM_063266912.1 → XP_063122982.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  25. XM_063266925.1 → XP_063122995.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

    UniProtKB/TrEMBL
    A6INM6

  26. XM_063266922.1 → XP_063122992.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  27. XM_039083228.2 → XP_038939156.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZL09
    Related
    ENSRNOP00000078532.1
    Conserved Domains (2) summary
    smart00036
    Location:1030 → 1328
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  28. XM_063266900.1 → XP_063122970.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZL09

  29. XM_063266927.1 → XP_063122997.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X47

    UniProtKB/TrEMBL
    A6INM6

  30. XM_063266915.1 → XP_063122985.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

    UniProtKB/TrEMBL
    A0A8I5ZL09

  31. XM_063266913.1 → XP_063122983.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  32. XM_063266921.1 → XP_063122991.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  33. XM_063266923.1 → XP_063122993.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

    UniProtKB/TrEMBL
    A6INM6

  34. XM_039083238.2 → XP_038939166.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

    UniProtKB/TrEMBL
    A0A8I5ZLV4
    Conserved Domains (2) summary
    smart00036
    Location:930 → 1236
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  35. XM_063266918.1 → XP_063122988.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

    UniProtKB/TrEMBL
    A0A8I5ZLV4, A0A8I5ZYP2

  36. XM_063266919.1 → XP_063122989.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  37. XM_008767014.4 → XP_008765236.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

    UniProtKB/TrEMBL
    A6INM6

  38. XM_063266926.1 → XP_063122996.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X46

    UniProtKB/TrEMBL
    A6INM6

  39. XM_039083234.2 → XP_038939162.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

    UniProtKB/TrEMBL
    A0A8I5ZL09
    Conserved Domains (2) summary
    smart00036
    Location:975 → 1273
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  40. XM_063266914.1 → XP_063122984.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

    UniProtKB/TrEMBL
    A0A8I5ZL09

  41. XM_063266920.1 → XP_063122990.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

    UniProtKB/TrEMBL
    A0A8I5ZLV4, A0A8I6AHN7

  42. XM_063266929.1 → XP_063122999.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X49

    UniProtKB/TrEMBL
    A0A8I5ZLV4

  43. XM_039083233.2 → XP_038939161.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

    UniProtKB/TrEMBL
    A0A8I5ZL09
    Conserved Domains (2) summary
    smart00036
    Location:976 → 1274
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  44. XM_008767011.4 → XP_008765233.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

    UniProtKB/TrEMBL
    A0A8I5ZL09

  45. XM_039083242.2 → XP_038939170.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

    UniProtKB/TrEMBL
    A0A8I5ZLV4
    Conserved Domains (2) summary
    smart00036
    Location:866 → 1164
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  46. XM_039083239.2 → XP_038939167.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

    UniProtKB/TrEMBL
    A0A8I5ZLV4
    Conserved Domains (2) summary
    smart00036
    Location:929 → 1227
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  47. XM_017596342.3 → XP_017451831.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

    UniProtKB/TrEMBL
    A0A8I5ZLV4, A0A8I6AT99
    Related
    ENSRNOP00000097771.1

  48. XM_039083243.2 → XP_038939171.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

    UniProtKB/TrEMBL
    A6INM6
    Conserved Domains (2) summary
    smart00036
    Location:835 → 1133
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  49. XM_063266928.1 → XP_063122998.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X48

    UniProtKB/TrEMBL
    A0A8I5ZL09

  50. XM_063266916.1 → XP_063122986.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

    UniProtKB/TrEMBL
    A0A8I5ZL09
Nucleotide Protein Strain
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