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Lman2l lectin, mannose-binding 2-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 301343, updated on 10-Oct-2024

Summary

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Symbol
Lman2lprovided by RGD
Full Name
lectin, mannose-binding 2-likeprovided by RGD
Primary source
RGD:1311393
See related
EnsemblRapid:ENSRNOG00000015699 AllianceGenome:RGD:1311393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein transport. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 25.4), Kidney (RPKM 25.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lman2l in Genome Data Viewer
Location:
9q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46157596..46181151, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38661709..38685244, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43020940..43023015, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene fer-1-like family member 5 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein. Nufer O, et al. J Biol Chem, 2003 May 2. PMID 12609988
  2. VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum. Neve EP, et al. Exp Cell Res, 2003 Aug 1. PMID 12878160
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
VIP36-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402076.1 → NP_001389005.1  VIP36-like protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6IND3
    Related
    ENSRNOP00000060837.4, ENSRNOT00000063781.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    46157596..46181151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266892.1 → XP_063122962.1  VIP36-like protein isoform X1

    UniProtKB/TrEMBL
    A6IND4
    Related
    ENSRNOP00000081479.1, ENSRNOT00000117761.2

  2. XM_039084532.2 → XP_038940460.1  VIP36-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4A4
    Conserved Domains (1) summary
    cl14058
    Location:16 → 145
    lectin_L-type; legume lectins

  3. XM_039084531.2 → XP_038940459.1  VIP36-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4A4
    Related
    ENSRNOP00000086744.1, ENSRNOT00000119365.2
    Conserved Domains (1) summary
    cl14058
    Location:16 → 145
    lectin_L-type; legume lectins

RNA

  1. XR_010054583.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106900.1: Suppressed sequence

    Description
    NM_001106900.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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