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wnt1 wingless-type MMTV integration site family, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 30128, updated on 2-Nov-2024

Summary

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Official Symbol
wnt1provided by ZNC
Official Full Name
wingless-type MMTV integration site family, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-526
See related
Ensembl:ENSDARG00000055554 AllianceGenome:ZFIN:ZDB-GENE-980526-526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
WNT-1; int-1; sb:eu647; zgc:194464; zgc:194478
Summary
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within brain development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See wnt1 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27652206..27661157)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27725225..27731712)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 8 Neighboring gene ADP-ribosylation factor 3a Neighboring gene wingless-type MMTV integration site family, member 10b Neighboring gene ribosomal protein S26 Neighboring gene IKAROS family zinc finger 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Direct visualization of the Wntless-induced redistribution of WNT1 in developing chick embryos. Galli LM, et al. Dev Biol, 2018 Jul 15. PMID 29715461, Free PMC Article
  2. Combined lineage mapping and gene expression profiling of embryonic brain patterning using ultrashort pulse microscopy and image registration. Gibbs HC, et al. J Biomed Opt, 2014 Dec. PMID 25539062
  3. Expression of wnt10a in the central nervous system of developing zebrafish. Kelly GM, et al. Dev Biol, 1993 Jul. PMID 8330668
  4. Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary. Krauss S, et al. Nature, 1992 Nov 5. PMID 1436081
  5. New insights into opioid regulatory pathways: influence of opioids on Wnt1 expression in zebrafish embryos. Sanchez-Simon FM, et al. Neuroscience, 2012 Jan 3. PMID 22062135

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the zebrafish, wnt1 and its neighboring paralog, wnt10b, are expressed in largely overlapping patterns, suggesting co-regulation; results suggest that the control of wnt1 and wnt10b expression is under complex regulation involving the interaction of multiple enhancers.
    Title: Analysis of the wnt1 regulatory chromosomal landscape.
  2. analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation
    Title: Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
  3. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
    Title: Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
  4. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
    Title: Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.
  5. The boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions.
    Title: Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain.
  6. novel role for Wnt/beta-catenin signalling in determining endocardial cell fate
    Title: The Wnt/beta-catenin pathway regulates cardiac valve formation.
  7. In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis
    Title: Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation.
  8. Wnt/Axin/beta-catenin pathway has a role in ventral CNS development
    Title: Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity.
  9. two Dvl-associated paralogs, Dpr1 and Dpr2, participate in distinct Wnt-dependent developmental processes
    Title: Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain segmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebellum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fourth ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein Wnt-1
Names
etID22400.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201398.1 → NP_001188327.1  protein Wnt-1 precursor

    See identical proteins and their annotated locations for NP_001188327.1

    Status: VALIDATED

    Source sequence(s)
    BC163014
    UniProtKB/Swiss-Prot
    P24257
    UniProtKB/TrEMBL
    B3DI55
    Related
    ENSDARP00000072397.2, ENSDART00000077931.3
    Conserved Domains (1) summary
    smart00097
    Location:59 → 370
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    27652206..27661157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162223.5 → XP_005162280.1  protein Wnt-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B987
    Conserved Domains (1) summary
    smart00097
    Location:64 → 375
    WNT1; found in Wnt-1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_130951.2: Suppressed sequence

    Description
    NM_130951.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24257.1 GenPept UniProtKB/Swiss-Prot:P24257

Gene LinkOut

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